Hyperuricemia and Associated Cardiometabolic Factors: A Cross-sectional Study on Taxi-motorbike Drivers Working in Cotonou, Benin
محل انتشار: مجله بیوشیمی پزشکی، دوره: 10، شماره: 1
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 77
فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_MEBIO-10-1_006
تاریخ نمایه سازی: 28 تیر 1402
چکیده مقاله:
Background: An elevated level of uric acid (UA), also known as hyperuricemia (HUA), contributes to the
occurrence of cardiovascular diseases (CVDs). However, epidemiolocal features of HUA in populations
of Benin are rare.
Objectives: We identified clinical and metabolic factors associated with HUA in taxi-motorbike drivers
(TMDs) of Cotonou.
Methods: A total of ۱۳۴ participants with a mean age of ۳۹.۳ years were analyzed using a retrospective
cross-sectional study design. Data from a self-administered questionnaire and biochemical markers
including, plasma UA, glucose, insulin, creatinine, and lipids were obtained from each participant. HUA
was defined as plasma UA greater than ۴۱۶ μmol/L. Insulin resistance (IR) was determined using the
homeostatic model assessment (HOMA). Logistic regression analysis was performed to determine the
association of various risk factors with HUA. Odds ratio (OR) and ۹۵% confidence interval (CI) were
calculated for HUA.
Results: The overall prevalence of HUA was ۱۹.۴% (۹۵% CI: ۱۲.۷-۲۶.۱) in TMDs. Multivariable logistic
regression showed that IR (OR = ۳.۶۰, ۹۵% CI: ۱.۲۷-۱۰.۲۲, P = ۰.۰۲), hypertension (OR = ۲.۷۵, ۹۵% CI: ۱.۰۰-
۷.۵۴, P = ۰.۰۵), and triglycerides (TG; OR = ۴.۲۵, ۹۵% CI: ۱.۳۹-۱۲.۹۸, P = ۰.۰۱) were risk factors for HUA.
Furthermore, creatinine was inversely associated with HUA (OR = ۰.۶۲, ۹۵% CI: ۰.۴۱-۰.۹۴, P = ۰.۰۲).
Conclusion: HUA was found in ۱۹.۴% of the patients. In addition, hypertension, IR, creatinine, and TG
levels were independently associated with HUA in TMDs. Therefore, the monitoring of these markers may
help prevent HUA.
کلیدواژه ها:
نویسندگان
Patrice Hodonou Avogbe
Laboratory of Biochemistry and Molecular Biology, Department of Biochemistry and Cellular Biology, Faculty of Science and Techniques, University of Abomey-Calavi, ۰۴ BP ۳۲۰, Cotonou, Benin
Ambalious Sanni
Laboratory of Biochemistry and Molecular Biology, Department of Biochemistry and Cellular Biology, Faculty of Science and Techniques, University of Abomey-Calavi, ۰۴ BP ۳۲۰, Cotonou, Benin