Immunomodulatory Effects of the Somatic Antigens of Fasciola Hepatica and Teladorgasia Circumcincta in Mice Immunized with Sheep Red Blood Cells
محل انتشار: مجله علوم پیشرفته زیست پزشکی، دوره: 11، شماره: 3
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 50
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شناسه ملی سند علمی:
JR_JABS-11-3_003
تاریخ نمایه سازی: 31 تیر 1402
چکیده مقاله:
Background & Objective: Infestation of humans with helminth parasites can reduce the severity of some auto-inflammatory symptoms in humans. This study was done to evaluate the impact of the somatic antigens extracted from Fasciola hepatica (as an indicator Trematode) ,and Teladorgasia circumcincta (as an indicator nematode) on the immune responses of NMRI mice challenged with sheep red blood cells (SRBCs).
Materials & Methods: The mice in treatment groups were intraperitoneally immunized with ۱×۱۰۹ SRBCs twice with ۱۴ days intervals. Concurrent with the immunization, the mice received the extract of each of the parasites (۵۰,۱۰۰. And ۱۵۰ µg of protein) or placebo, throughout the study on a daily basis. The specific cellular immune responses and the anti-SRBC antibody titers were detected by footpad thickness and, microhemagglutination test, respectively. Splenocytes were also monitored for cytokine production, proliferation rate, and respiratory burst.
Results: The extracts of F. hepatica and T. circumcincta had an opposite effect on the change of the Anti-sRBC antibody level. The extract of F. hepatica caused a significant decrease in the antibody level whereas, extract T. circumcincta did not show any significant changes in the anti-SRBC antibody. Both extracts caused a significant decrease in the level of delayed-type hypersensitivity. However, the extract of F. hepatica caused a more profound reduction in the severity of delayed-type hypersensitivity. The level of IFN-γ in the splenocytes of immunized mice receiving the F. hepatica showed a more pronounced decrease than the immunized mice receiving the extract of T. circumcincta extract. IL-۱۰ levels were only increased in the immunized mice that received the extract of F. hepatica.
Conclusion: The extract of F. hepatica may have an immunosuppressive property, while the extract of T. circumcincta may have immunomodulatory properties.
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نویسندگان
علی مرادیان
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia Iran
سید میثم ابطحی فروشانی
Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia Iran
بیژن اسمعیل نژاد
Department of Pathobiology, Faculty of veterinary Medicine, Urmia University, Urmia, Iran
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