Personalized Medicine for Antibiotics: Pharmacological Displacement of Thiocolchicosidum as Antimicrobial Agent
محل انتشار: فصلنامه پزشکی شخصی، دوره: 8، شماره: 29
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 77
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شناسه ملی سند علمی:
JR_PMJ-8-29_004
تاریخ نمایه سازی: 1 مرداد 1402
چکیده مقاله:
Due to the increasing level of bacterial antibiotic resistance (AB), it is now required to modify the dosage for customized medication using therapeutic drug monitoring. The creation of a novel treatment for clinical use, such as situations of bacterial resistance, has been hailed as a feasible, affordable, and quick alternative by the pharmaceutical industry. Therefore, the current research sought to examine the myorelaxant Thiocolchicosidum's antibacterial activity against bacterial strains. Staphylococcus aureus ATCC ۲۵۹۲۳, Escherichia coli ATCC ۲۵۹۲۲, Proteus mirabilis ATCC ۲۵۹۳۳, and Pseudomonas aeruginosa ATCC ۲۷۸۵۳ were used as the bacteria in an in vitro experimental study, along with the protocols for antibacterial activity screening, minimum inhibitory concentration (MIC), and characterization of antibacterial activity. Thiocolchicosidum, at levels varying from ۰.۴۸ to ۱۰۰۰ µg/mL, was the chemical. The only bacterial strains that showed any sensitivity to the myorelaxant were E. coli and P. aeruginosa, both of which had MICs of ۵۰۰ µg/mL and ۱۰۰۰ µg/mL, respectively. Thiocolchicosidum demonstrated a bacteriostatic effect in the antimicrobial characterization test. Therefore, despite the fact that this medication is already considered safe for human use, no discernible antibacterial effects were shown in common bacterial strains. Therefore, research is required to determine how it differs from other microbes, such as various kinds of bacteria, fungus, and protozoa, in order to rule it out as a potential antibiotic material for use in industry.
کلیدواژه ها:
نویسندگان
Farhad Jafari-Berenjestanaki
Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University, Tehran Pishva Branch, Varamin, Iran
Faeze Hasani
Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University, North Tehran Branch, Tehran, Iran
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