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مقالات فارسیISIکنفرانسهاژورنالها

The Relationship between Thyroid Hormone Levels and Body Iron Status in Iranian Hypothyroidism Patients

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 3، شماره: 3
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 104

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https://civilica.com/doc/1713391

شناسه ملی سند علمی:

JR_JIML-3-3_005

تاریخ نمایه سازی: 14 مرداد 1402

چکیده مقاله:

Backgrounds and Aims: Thyroid hormones have a crucial physiological role to maintain balance of metabolism of body. Thyroid hormones have an important role in metabolism and proliferation of blood cells. Thyroid gland also has a vital influence on erythropoiesis by induction of erythropoietin secretion and proliferation of erythroid progenitors. In the present study, it was tried to evaluate the effect of hypothyroidism on hematological parameters and also body iron store. Materials and Methods: The research population consisted of ۹۰ subjects divided into two groups: ۴۵ people with hypothyroidism and ۴۵ age-matched healthy individuals. This study checked the amounts of total triiodothyronine (T۳), total thyroxine (T۴), thyroid stimulating hormone (TSH), and some iron status and hematological parameters. Results: The mean TSH levels were significantly increased in hypothyroid patients compared to control group. On the other hand, the levels of T۴ and total iron binding capacity, serum iron, ferritin, Hemoglobin, and Hematocrit were significantly lower in hypothyroid patients compared to control group (p<۰.۰۵). However, there was no significant difference in the mean of T۳ between hypothyroidism and control. Conclusion: Our data suggest that alterations in thyroid status change serum iron metabolism and hematological index. Hypothyroidism is often associated with anemia,depleted body iron store. As there is no significant clinical manifestation of hypothyroidism at earlier stages with anemia, it is advisable to routinely investigate it for early detection allowing its early management.

کلیدواژه ها:

Ferritin ، Hyperthyroidism ، Serum iron ، TIBC

نویسندگان

Niko Rostaei Rad

Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Mahmood Vakili

Department of Community Medicine, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. ۳Department

Javad Zavar-reza

Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Sona Rezaie

Department of Clinical Biochemistry, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Ahmad Reza Shirvani

Department of Clinical Laboratory Sciences, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

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  • ۱]. Guerrero A, Pamplona R, Postero-Otin M, López-Torres M. Effect ...
  • ۲]. Chu JY, Monteleone JA, Peden VH, Graviss ER, Vernava ...
  • Phila]. ۱۹۸۱; ۲۰ (۱۱): ۶۹۶-۹۹ ...
  • ۳]. Franzese A, Salemo M, Argenziano A, Buongiovanni C, Limauro ...
  • ۴]. Lippi G, Montagnana M, Salvagno GL, Guidi GC. Should ...
  • ۵]. Leedman JP, Stein AR, Chin WW, Rogers JT. Thyroid ...
  • ۶]. Levenson CW, Fitch CA. Affect of altered thyroid hormon ...
  • ۷]. Bothwell TH, Charlton RW, Cook JB, Finch CA. Iron ...
  • ۸]. Dallman PR, Beutler E, Finch CA. Effects of iron ...
  • ۹]. Zwirska-Korczala K, Buntner B, Sobieraj H, Ostrowska Z, Kniazewski ...
  • ۱۰]. Sakata S, Nagai K, Maekawa H, Kimata Y, Komaki ...
  • ۱۱]. Lingidi JL, Mohapatra E, Zephy D, Kumari S. Serum ...
  • ۱۲]. Mackenzie GM. Anemia in hypothyroidism. JAMA. ۱۹۲۶; ۸۶(۷): ۴۶۲-۶۴ ...
  • ۱۳]. Fein HG, Rivlin RS. Anemia in thyroid diseases. Med ...
  • ۱۴]. Lima CS, ZantutWittmann DE, Castro V, Tambascia MA, Lorand-Metze ...
  • ۱۵]. Kawa MP, Grymuła K, Paczkowska E, Baśkiewicz-Masiuk M, Dąbkowska ...
  • ۱۶]. Golde DW, Bersch N, Chopra IJ, Cline MJ. Thyroid ...
  • ۱۷]. Das KC, Mukherjee M, Sarkar TK, Dash RJ, Rastogi ...
  • ۱۸]. Dorgalaleh A, Mahmoodi M, Varmaghani B, Kiani node F, ...
  • ۱۹]. Geetha J, Srikrishna R. Role of red blood cell ...
  • ۲۰]. Kubota K., Kurabayashi H., Tamura J, Kawada E, Tamura ...
  • ۲۱]. Seven A, Toktamis N, Hacibekiroglu M, Candan G, Yigit ...
  • ۲۲]. Winkleman JC, Mariash CN, Towle HC, Oppenheimer JH. Thyroidectomy ...
  • ۲۳]. Jump DB, Mariash CN, Oppenheimer JH. Evidence for post-transcriptional ...
  • ۲۴]. Deshpande UR, Nadkarni GD. Relation between thyroid status and ...
  • ۲۵]. Iwasa Y, Aida K, Yokomori N, Inoue M, Onaya ...
  • ۲۶]. Macaron CI, Macaron ZG. Increased serum ferritin levels of ...
  • ۲۷]. Van de Vyver FL, Blockx PP, Van den Bogaert ...
  • ۲۸]. Takamatsu J, Majima M, Miki K, Kuma K, Mozai ...
  • ۲۹]. Hashimoto T, Matsubara F. Changes in the tumor marker ...
  • ۳۰]. Kubota K, Tamura J, Kurabayashi, Shirakura T, Kobayashi. Evaluation ...
  • ۳۱]. Perrin MC, Blanchet JP, Mouchiroud G. Modulation of human ...
  • ۳۲]. Cinemre H, Bilir C, Gokosmanoglu F, Bahcebasi T. Effects ...
  • ۳۳]. Duntas LH, Papanastasiou L, Mantzou E, Koutras DA. Incidence ...
  • ۳۴]. Christ-Crain M, Meier C, Huber P, Zulewski H, Staub ...
  • ۳۵]. Touam M, Gue´ry B, Goupy C, Menoyo V, Drüeke ...
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