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مقالات فارسیISIکنفرانسهاژورنالها

In Vitro Toxicity of the Naked and Serum-treated Nanoparticles on Cardiomyocytes

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 2، شماره: 3
سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 78

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استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1713400

شناسه ملی سند علمی:

JR_JIML-2-3_004

تاریخ نمایه سازی: 14 مرداد 1402

چکیده مقاله:

Background and Aims: Although metal and metal oxide nanoparticles are used in different medical applications, they may have considerable toxicity on various cells, such as myocytes. Therefore, this study aimed to evaluate the toxicity of the naked and serum-treated silver nanoparticles (Ag NPs) and magnesium oxide nanoparticles (MgO NPs) on the cardiomyocytes. Materials and Methods: Cardiomyocytes were separately exposed to different concentrations of the naked and serum-treated nanoparticles for ۲۴ hours at ۳۷ºC. Then, MTT assay, cell metabolism assay and LDH assay were performed. Results: Naked Ag NPs and MgO NPs had more toxicity than serum-treated nanoparticles. The highest cardiomyocyte toxicity was observed for naked Ag NPs, whereas the minimum toxicity was seen for the serum-treated MgO NPs. Conclusions: Coating of nanoparticles with serum components leads to decrease in toxicity for cardiomyocytes, and MgO NPs have less toxicity on the myocytes than Ag NPs.

کلیدواژه ها:

Cardiomyocyte ، Magnesium oxide ، Nanoparticles ، Silver ، Toxicity ، -

نویسندگان

Seyedhossein Hekmatimoghaddam

Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Ali Jebali

Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Bahram kazemi

Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ۳Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mohammadagha Ayatollahi

Pharmaceutical Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

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