Investigating Class I, II and III Integrons in Multidrug Resistance in Pseudomonas aeruginosa Isolated from Hospital Infections in Ahvaz

سال انتشار: 1394
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 53

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شناسه ملی سند علمی:

JR_JIML-2-3_003

تاریخ نمایه سازی: 14 مرداد 1402

چکیده مقاله:

Background and Aims: The indiscriminate use of antibiotics can lead to antibiotic resistance in the treatment of infections caused by bacteria such as Pseudomonas aeruginosa. The presence of integrons in Pseudomonas is clearly associated with multidrug resistances. Therefore, this study aimed at tracking class I, II and III integrons of antibiotic-resistant isolates of Pseudomonas aeruginosa that were isolated from nosocomial infection. Materials and Methods: In this study, ۵۱ isolates of Pseudomonas aeruginosa were collected from different wards of Imam Khomeini hospital of Ahvaz since October of ۲۰۱۴ until March of ۲۰۱۵. After identification test and antibigram, coding genes of antibiotic resistance and class I, II and III integrons were detected by polymerase chain reaction (PCR) method. Results: Tetracycline revealed the most resistance with ۸۴% frequency in discreted isolates. In the encoding antibiotic resistance genes with a frequency of ۹۴% was the most common blaTEM. Class I integron had ۹۲% prevalence, class II Integron showed ۵۲% prevalence and class III Integron demonstrated ۱۷% prevalence. Conclusions: In Pseudomonas aeruginosa, class I integron was more prevalent than other integrons and the integrase gene was probably one of the causes of multiple antibiotic resistance in this bacteria. Moreover, frequency of integron III  was  reported ۱۷%.

نویسندگان

Parvin Hosseini Pour

Microbiology Department, Shahrekord Islamic Azad University, Shahrekord, Iran.

Hassan Momtaz

Microbiology Department, Shahrekord Islamic Azad University, Shahrekord, Iran

Amir Arsalan Serajyan

.Health Education Research, Jahad Daneshgahi of Khuzestan, Ahvaz, Iran.

Elahe Tajbakhsh

Microbiology Department, Shahrekord Islamic Azad University, Shahrekord, Iran.

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