The Ameliorating Role of Oral Administration of Basella Alba Methanol Extract in Nicotine-Induced Testicular Toxicity
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 84
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شناسه ملی سند علمی:
JR_PJMT-12-2_009
تاریخ نمایه سازی: 31 مرداد 1402
چکیده مقاله:
Background: Nicotine is a potential cause of male infertility due to its ability to induce testicular damage. This study investigated the influence of Basella Alba (BA) on possible nicotine-induced testicular damage.Methods: Twenty male Wistar rats were divided into four random groups namely; healthy control (HC) in which rats were administered only normal saline, Nicotine control (NC) which received high dose nicotine only (۱.۰mg/kg), Low dose nicotine, Basella Alba treatment group (LDN + BA) given nicotine (۰.۵mg/kg) plus methanol extract of Basella Alba (۲۰۰mg/kg) and High dose nicotine, Basella Alba treatment group (HDN + BA) in which rats received nicotine (۱.۰mg/kg) plus Basella Alba extract (۲۰۰mg/kg). Rats were euthanized via exsanguination after five weeks of treatment and testes extracted for histological analysis. Blood samples were also analyzed for gonadal hormones.Results: There was a significant decline (p<۰.۰۵) in body weight, testicular weight, and serum testosterone but elevated follicle stimulating hormone (FSH) and luteinizing hormone (LH) in NC rats when compared with HC. Rats in LDN + BA and HDN + BA showed a significant increase (p<۰.۰۵) in serum testosterone and a corresponding decrease (p<۰.۰۵) in FSH and LH levels when compared to rats in NC. Additionally, testicular photomicrographs revealed significant histoarchitectural distortions in NC rats when compared to HC. These anomalies were found to be either milder or absent in LDN + BA and HDN + BA groups.Conclusions: Nicotine induces both structural and functional testicular damage that is ameliorated by Basella Alba possibly due to the high antioxidant composition.
نویسندگان
Dennis Arokoyo
Department of Physiology, College of Health Sciences, Osun State University, Osogbo, Osun State
Oluwatimilehin Ajayi
۲. Department of Physiology, Faculty of Basic Medical and Health Sciences, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria.
Awwal Badamasi
۳. Department of Public Health, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
Olubayode Bamidele
۲. Department of Physiology, Faculty of Basic Medical and Health Sciences, College of Health Sciences, Bowen University, Iwo, Osun State, Nigeria
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