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مقالات فارسیISIکنفرانسهاژورنالها

INF/IL-۴ increases after the low doses of gamma radiation in BALB/c spleen lymphocytes

محل انتشار: مجله فیزیک پزشکی ایران، دوره: 16، شماره: 4
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 73

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لینک ثابت به این مقاله:
https://civilica.com/doc/1738930

شناسه ملی سند علمی:

JR_IJMP-16-4_002

تاریخ نمایه سازی: 5 شهریور 1402

چکیده مقاله:

Introduction: The effects of the low dose of ionizing radiation are not thoroughly evident due to an unavoidable increase of occupational exposure and the widespread application of ionizing radiation in medical and industrial fields. The aim of this study was to investigate immune system responses following the low doses of ionizing radiation. Material and Methods: BALB/c mice were exposed to Whole Body Irradiation of ۲۰, ۵۰, and ۱۰۰ mGy through a ۶۰Co source. Lymphocytes extraction were operated ۲۴ h after irradiation. Afterwards, gene expression analysis was performed with relative quantitative Real-Time polymerase chain reaction to IL-۴, IFN-γ, and TGF-β expression levels. Moreover, IFN-γ/IL-۴ ratio was computed, and the independent sample t-test was performed for the statistical analysis. Results: Whereas IL-۴, IFN-γ, and TGF-β expression levels decrease after the radiation of the low doses of gamma rays, the IFN-γ/IL-۴ ratio increased significantly after irradiation of ۲۰ mGy (P-Value<۰.۰۵). However, this ratio did not vary following the gamma irradiation of ۵۰ and ۱۰۰ mGy. Conclusion: The positive effects of the low dose of ionizing radiation can be observed through significant alterations in gene expression and the activation of protection mechanisms. This process was caused by the modulation of cellular immune responses after the exposure to ۲۰ mGy. Although the irradiation of higher doses (۵۰ and ۱۰۰ mGy) induced alterations in the IFN- γ/IL-۴ ratio was insignificant. These findings did not confirm the linear no-threshold model theory, and demonstrated that the low dose of ionizing radiation could be the cause of the hormesis phenomenon.

کلیدواژه ها:

BALB/c mice ، Ionizing radiation ، IFN-gamma ، Interleukin-۴ ، TGF-beta

نویسندگان

Mohammad Taghi Bahreyni Toossi

Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Maryam Najafi Amiri

Medical Physics Department,Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mojtaba Sankian

Immunobiochemistery lab, Bu-Ali (Avecina) Research center, Mashhad University

Hosein Azimian

Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Sepide Abdollahi Dehkordi

Medical Physics Department,Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

SARA KHADEMI

Department of Radiology Technology, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran

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  • ReferencesKudo T, Ideguchi R. The effects of medical radiation: A ...
  • Siegel JA, Pennington CW, Sacks B. Subjecting radiologic imaging to ...
  • Desouky O, Ding N, Zhou G. Targeted and non-targeted effects ...
  • Sies H, Feinendegen LE. Radiation hormesis: the link to nanomolar ...
  • Shirazi MM, Shabestani-Monfared A, Shahidi M, Amiri M, Abedi SM, ...
  • Jolly D, Meyer J. A brief review of radiation hormesis. ...
  • Sykes PJ. The ups and downs of low dose ionising ...
  • Song K-H, Kim M-H, Kang S-M, Jung S-Y, Ahn J, ...
  • Gyuleva IM, Penkova KI, Rupova IT, Panova DY, Djounova JN. ...
  • Liu S-Z. Cancer control related to stimulation of immunity by ...
  • Yagunov A, Tokalov S, Chukhlovin A, Afanassiev B. Animal Studies ...
  • Ina Y, Sakai K. Prolongation of life span associated with ...
  • Zhikrevetskaya S, Peregudova D, Danilov A, Plyusnina E, Krasnov G, ...
  • Shigematsu A, Adachi Y, Koike-Kiriyama N, Suzuki Y, Iwasaki M, ...
  • Kojima SM, Matsumori S, Ishida H, Yamaoka K . Possible ...
  • McColl N, Auvinen A, Kesminiene A, Espina C, Erdmann F, ...
  • Richardson DB, Cardis E, Daniels RD, Gillies M, O’Hagan JA, ...
  • Pearce MS, Salotti JA, Little MP, McHugh K, Lee C, ...
  • Wise K. Solid cancer risks from radiation exposure for the ...
  • Bogdándi EN, Balogh A, Felgyinszki N, Szatmári T, Persa E, ...
  • Shin SC, Lee K-M, Kang YM, Kim K, Kim CS, ...
  • Heidari S, Taheri M, Ravan AP, Moghimbeigi A, Mojiri M, ...
  • Saito S, Sakai M. Th۱/Th۲ balance in preeclampsia. Journal of ...
  • Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, ...
  • Feinendegen L. Evidence for beneficial low level radiation effects and ...
  • Azimian H, Bahreyni-Toossi MT, Rezaei AR, Rafatpanah H, Hamzehloei T, ...
  • Liu S-Z. Nonlinear dose-response relationship in the immune system following ...
  • In vivo Exposure Effects of 99mTc-methoxyisobutylisonitrile on the FDXR and XPA Genes Expression in Human Peripheral Blood Lymphocytes [مقاله ژورنالی]
  • Bahreyni-Toossi MT, Azimian H, Rezaei AR, Rafatpanah H, Hamzehloei T, ...
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