Quercetin loaded albumin nanoparticles: Synthesis and release kinetic study

One of the ways to improve release behavior and efficiency of hydrophobic pharmaceutical compounds in the aqueous environment of the body is loading of these drugs in delivery systems. In this regard, nanoparticles-based drug delivery systems (DDSs) have shown a great potential. In this study, albumin nanoparticles were prepared as a delivery system for hydrophobic quercetin compound. According to the FESEM imaging, prepared nanoparticles showed mean particle size of ۱۱۶.۵۸ ± ۲.۶۵ nm with spherical and uniform morphology. Also, the results of the in vitro release study showed that the release of quercetin from albumin nanoparticles occurs in a controlled and sustained manner. Finally, the fitting of the release data on Zero-order, First-order and Higuchi kinetic models showed that the release mechanism mainly follows the Higuchi model.