Matrix Metalloproteases ۸ Polymorphism as Risk Factor for Rotator Cuff Tear
محل انتشار: مجله استخوان و جراحی عمومی، دوره: 11، شماره: 9
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 98
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شناسه ملی سند علمی:
JR_TABO-11-9_003
تاریخ نمایه سازی: 19 شهریور 1402
چکیده مقاله:
Objectives: Rotator Cuff Tear (RCT) is a multifactorial disease, but an important one is the increased collagen degradation that would lead to a higher chance of tear. MMP-۸ is a protein that degrades type I collagen, and it is known that MMP-۸ has a polymorphism in which a T allele in the gene promoter region increases its transcription activity. This study aims to investigate the association between MMP -۸ polymorphism g.-۷۹۹ C>T (rs۱۱۲۲۵۳۹۴) and RCT.Methods: To do that, we collected DNA samples from buccal epithelial cells of ۱۲۸ patients (separated into RCT group and control group in a proportion ۱:۱) and genotyped the DNA using PCR. The statistical analyses were done using the ARLEQUIN Version ۲.۰, and the data normality was tested with the Shapiro-Wilk test.Results: The results showed a significantly higher frequency of T/T genotype in the test group (۲۹% in the control group and ۳۹% in the test group, p=۰.۰۴۱۷), and that would represent a risk factor for increased collagen degradation.Conclusion: The MMP-۸ g.-۷۹۹ C>T (rs۱۱۲۲۵۳۹۴) SNP was associated with RCT. With the description of a new risk factor, future research can be done to analyze how to prevent RCT or develop new treatment strategies since the disease's failure index is currently high. Level of evidence: II
کلیدواژه ها:
نویسندگان
Nathali Cavascan
Department of Cell Biology, University Federal of Paraná, Curitiba, PR, Brazil
Jorge Assunção
Department of Orthopedics and Traumatology, University of São Paulo, São Paulo, SP, Brazil
Alexandre Godoy-Santos
Department of Orthopedics and Traumatology, University of São Paulo, São Paulo, SP, Brazil
Arnaldo Ferreira Neto
Department of Orthopedics and Traumatology, University of São Paulo, São Paulo, SP, Brazil
Maria Cristina Santos
Department of Cell Biology, University Federal of Paraná, Curitiba, PR, Brazil
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