Wind loads of high-rise buildings are a key parameter in architectural design. The magnitude and distribution characteristics of wind loads are of great importance for the safety and economy of structural design. The wind loads of high-rise buildings are quite different from those of monomer buildings. The wind-induced interference effect could significantly increase the local wind pressure of buildings, causing potential safety hazards for the main structure and enclosure structure. For the three common high-rise buildings, we adopted the wind tunnel test method to measure the surface pressure of each building. The corresponding Re number was ۸.۲×۱۰۶. This paper studied the shape coefficients, fluctuating wind pressure coefficients and base bending moment coefficient of each building with different wind direction angles and different spacing ratios, and the maximum value of each parameter and the corresponding working condition were statistically analyzed. The results showed that, under any wind direction angle, the fluctuating wind pressure coefficients on all sides of the building were affected by the spacing ratio, and the fluctuation range was large. When the wind angle was ۱۸۰º, the fluctuating wind pressure coefficients on the sides of Building ۱ were most affected by the slope ratio. At this wind angle, the maximum value was ۰.۴۳ at a slope ratio of ۵.۰, which was ۶۵% different from the minimum. Partition shape coefficients of some sides and top surfaces changed significantly with the spacing ratio. When the spacing ratio was ۵.۰, the base bending moment coefficients in the downwind and crosswind directions reached their maximum values, and the wind direction angles where the maximum values of the base bending moment coefficients in the downwind direction were ۴۰º and ۵۰º, respectively, and the wind direction angle where the maximum value of the base bending moment coefficients in the crosswind direction was ۱۰º. Due to the influence of the wind angle and the building spacing ratio, the wind loads on the facades of the pyramidal group of buildings varied greatly, and the wind-induced interference effect was evident. The wind load between the building facades in the three buildings was different, and the wind disturbance effect was evident. Therefore, the most unfavorable stress state and interference state of the structure should be comprehensively considered in the wind resistance design of the three buildings. The building spacing ratio should preferably be set to ۳.۰, and wind angles of ۱۰º, ۴۰º, and ۵۰º should be avoided whenever possible.