Green Multicomponent Synthesis of Benzodiazepines in the Presence of CuFe۲O۴ as an Efficient Magnetically Recyclable Nanocatalyst under Solvent-Free Ball-Milling Conditions at Room Temperature
محل انتشار: دوفصلنامه تحقیقات شیمی آلی، دوره: 4، شماره: 1
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 69
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شناسه ملی سند علمی:
JR_ORGC-4-1_008
تاریخ نمایه سازی: 3 مهر 1402
چکیده مقاله:
In this work, an efficient and green procedure for the synthesis of various substituted ۱,۵-benzodiazepine derivatives via a one-pot three-component catalytic reaction has been described. The reaction was conducted between o-phenylenediamine, dimedone and aldehyde derivatives in the presence of CuFe۲O۴ nanoparticles as a magnetic heterogeneous nanocatalyst under ball-milling conditions at room temperature. High yields of the products, short reaction times, simplicity of operation, mild reaction conditions, non-toxicity, easy work-up and purification of the products through crystallization method (chromatography-free) and recyclability of the catalyst are added advantages of this work.
کلیدواژه ها:
نویسندگان
Ali Maleki
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran ۱۶۸۴۶-۱۳۱۱۴, Iran
Razieh Firouzi-Haji
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran ۱۶۸۴۶-۱۳۱۱۴, Iran
Parisa Farahani
Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran ۱۶۸۴۶-۱۳۱۱۴, Iran