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مقالات فارسیISIکنفرانسهاژورنالها

Evaluation of Biological Markers in Children's Cerebrospinal Fluid with Bacterial and Viral Meningitis

محل انتشار: مجله بین المللی آزمایشگاه پزشکی، دوره: 10، شماره: 3
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 117

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لینک ثابت به این مقاله:
https://civilica.com/doc/1778519

شناسه ملی سند علمی:

JR_JIML-10-3_003

تاریخ نمایه سازی: 19 مهر 1402

چکیده مقاله:

Background and Aims: Cerebrospinal fluid (CSF) and blood biomarkers are widely evaluated as diagnostic tools to distinguish between bacterial meningitis and viral meningitis in emergency laboratory tests. So, this aimed to examine the levels of diagnostic parameters in blood and CSF to discriminate between bacterial and viral meningitis in young children referred to Khoy Hospital. Materials and Methods: A total of ۱۰۱ young children with meningitis were enrolled in this prospective study. The diagnosis of bacterial and viral meningitis was based on clinical features and laboratory findings. Results: Of the ۱۰۱ patients with meningitis, ۱۸ (۱۷.۸۲%) were bacterial, and ۸۳ (۸۲.۱۷%) were viral meningitis. The levels of CSF glucose and CSF/blood glucose ratio were significantly lower in the bacterial meningitis group than in the viral meningitis group (p < ۰.۰۱). In contrast, white blood cells count, CSF protein, interleukin-۶, C-reactive protein, and ferritin levels were significantly higher in patients with bacterial meningitis compared to viral meningitis (p < ۰.۰۱). However, there was no difference between viral and bacterial meningitis groups concerning mean serum glucose. Conclusion: This study suggests that decreased CSF glucose and CSF/blood glucose ratio and increased white blood cells count, CSF protein, ferritin, interleukin-۶, and C-reactive protein combined with clinical symptoms can help better diagnosis of bacterial meningitis, especially in comparison with viral meningitis.

کلیدواژه ها:

Bacterial meningitis ، Biological marker ، Cerebrospinal fluid ، Viral meningitis

نویسندگان

محمد پنجی

Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

وحیده بهمرد

Student Research Committee, Department of Midwifery, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

مهری فلاح رﯮفی

Department of Clinical Science, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

الناز سادات موسوی صدر جدیدی

Department of Basic Sciences, Payame Noor University, Tehran, Iran

الهام رستمی

Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

راحیل نوربخش

Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

وجیهه نجفی

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

توحید مرادی گردشی

Department of Veterinary Sciences, Garmsar Branch, Islamic Azad University, Garmsar, Iran

فهیمه صفی زاده

Iranian Social Security Organization, Kerman, Iran

هاله برمکی

Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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