Grape Seed Extract Loaded Amino Functionalized SBA-۱۵ Mesoporous Silica Nanoparticles as a potential drug delivery System: Antibacterial activity and release kinetics studies

Mesoporous silica nanoparticles (MSNs) are used as efficient carrier candidate for the delivery of the bioactive molecules, proteins, and drugs because of their properties such as safety, stability, biocompatibility, high surface area and controllable pore sizes with the narrow distribution and facile surface modification. MSNs demonstrate high encapsulation capability for both hydrophilic and hydrophobic drugs.In this study, SBA-۱۵ MSN was synthesized by hydrothermal method in acidic media and functionalized by post-grafting method using ۳-aminopropyltriethoxysilane. The efficiency of amino functionalized SBA-۱۵ MSN (SBA-۱۵-NH۲) was investigated for the loading and release of grape seed extract (GSE). The disc diffusion assay indicated GSE and GSE loaded on SBA-۱۵-NH۲ (SBA-۱۵-NH۲@GSE) at the concentration of ۳۲ mg/ml extract per disc resulted to in the inhibition zone of ۲۴ mm and ۱۵ mm for S. aurous and ۲۲ mm and ۱۳ mm for E. coli, respectively. The antibacterial effect improved by increasing concentration of GSE loaded into SBA-۱۵-NH۲ from ۲ to ۳۲ mg/ml. These results indicate that SBA-۱۵-NH۲@GSE owns a strong antibacterial potential valuable for the pharmaceutical industry.