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مقالات فارسیISIکنفرانسهاژورنالها

Association between Torque Teno Virus Frequency and Systemic Lupus Erythematosus: A Potential Trigger for Autoimmune Diseases

محل انتشار: فصلنامه عفونت، اپیدمیولوژی و پزشکی، دوره: 9، شماره: 3
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 69

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لینک ثابت به این مقاله:
https://civilica.com/doc/1783880

شناسه ملی سند علمی:

JR_IEM-9-3_005

تاریخ نمایه سازی: 29 مهر 1402

چکیده مقاله:

Aims: Infectious agents are considered as one of the possible etiological factors of systemic lupus erythematosus (SLE). It has been suggested that torque teno virus (TTV) may trigger autoimmune disorders, but few studies have been conducted on the relationship between this virus and autoimmune diseases, especially SLE. The present study aimed to evaluate the association between TTV frequency and SLE. Materials & Methods: Serum samples were collected from a total of ۱۱۶ participants, including ۵۸ healthy people and ۵۸ SLE patients who referred to the rheumatology clinic of Shahid-Beheshti hospital in Kashan, Iran from January ۲۰۲۰ to January ۲۰۲۱. After the extraction of viral DNA from the samples, a nested PCR test was performed using specific primers to detect TTV. Findings: TTV was detected in ۴۳ SLE patients (۷۴.۱%, ۹۵% CI: ۶۳.۴-۸۶.۲) and ۳۳ healthy individuals (۵۶.۹%, ۹۵% CI: ۴۴.۱-۶۹.۰). A significant correlation was found between SLE and the presence of TTV (r= .۳۲, p= .۰۳). There was no correlation between the presence of TTV and musculoskeletal involvements, skin lesions, renal manifestations, and hematological manifestations (r< .۰۵, p> .۰۵). TTV was detected more frequently in patients with active lupus than in patients with quiescent disease, and this difference was significant (p= .۰۴۸). Conclusion: A significant association between TTV and SLE was observed in the present study; however, further studies are needed to investigate the role of TTV in the pathogenesis and clinical course of SLE.

کلیدواژه ها:

Autoimmune Diseases ، Systemic Lupus Erythematosus ، Torque teno virus

نویسندگان

Mohammad shayestehpour

Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Faezeh Ebneali

Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Batool Zamani

Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Ahmad Piroozmand

Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Kamal Esalatmanesh

Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran

Zahrasadat Fateminasab

Department of Microbiology and Immunology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Shaghayegh Yazdani

Department of Microbiology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

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  • Zhao J, You X, Zeng X. Research progress of BK ...
  • Quaglia M, Merlotti G, De Andrea M, Borgogna C, Cantaluppi ...
  • Jog NR, James JA. Epstein Barr virus and autoimmune responses ...
  • Blazsek A, Sillo P, Ishii N, Gergely Jr P, Poor ...
  • Siahpoush M, Noorbazargan H, Kalantari S, Shayestehpour M, Yazdani S. ...
  • Moghimi M, Shayestehpour M, Doosti M, Vasmehjani AA, Ahmadi AS, ...
  • Webb B, Rakibuzzaman A, Ramamoorthy S. Torque teno viruses in ...
  • Swedan S, Al-Saleh D. Transfusion transmitted virus and dengue virus ...
  • Gergely Jr P, Pullmann R, Stancato C, Otvos Jr L, ...
  • Costa MR, Costa IP, Devalle S, Castro AR, Freitas SZ. ...
  • Petri M. Review of classification criteria for systemic lupus erythematosus. ...
  • Seemayer C, Viazov S, Neidhart M, Brühlmann P, Michel B, ...
  • Shirai T, Hirose S. Molecular pathogenesis of SLE. Springer Semin ...
  • Kooistra K, Zhang YH, Henriquez NV, Weiss B, Mumberg D, ...
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  • Negative N(%) P ValueClinical sign Musculoskeletal involvement ۳۵ (۷۳) ۱۳ ...
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  • Renal manifestation ۱۴ (۷۰) ۶ (۳۰) .۱۷ ...
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