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مقالات فارسیISIکنفرانسهاژورنالها

Expression of Galectin-۹-related immune checkpoint receptors in B-cell acute lymphoblastic leukemia

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 12
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 74

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1797023

شناسه ملی سند علمی:

JR_IJBMS-26-12_012

تاریخ نمایه سازی: 7 آبان 1402

چکیده مقاله:

Objective(s): Exhausted CD۸+ T-cells over-express immune checkpoint receptors (ICRs), which interact with their ligands on malignant cells. However, some ICRs have been reported to be expressed on both T-cells and tumor cells, including V-domain immunoglobulin suppressor of T cell activation (VISTA), Galectin-۹, and T-cell immunoglobulin mucin-۳ (TIM-۳). We aimed to evaluate the mRNA expression of VISTA, Galectin-۹, and TIM-۳ on CD۸+ T-cells and leukemic cells in B-cell acute lymphoblastic leukemia (B-ALL).Materials and Methods: Samples were obtained from ۲۶ untreated B-ALL patients and ۲۵ control subjects. CD۸+ T-cells were isolated using Magnetic Activated Cell Sorting (MACS). Relative gene expression was then evaluated by qRT-PCR with specific primers for VISTA, Galectin-۹, and TIM-۳. Also, the mRNA expression profile and clinical data of ۱۵۴ B-ALL patients were obtained from the TARGET.Results: mRNA expression of Galectin-۹ on CD۸+ T-cells in B-ALL patients was significantly lower than those in the control group (P=۰.۰۴۳), while VISTA expression was not significantly different between the two study groups (P=۰.۲۵۹). Besides, TIM-۳ expression was significantly higher in B-ALL patients than in the control group (P<۰.۰۰۱). Also, data obtained from TARGET showed that the relapse incidence was not significantly different between patients with high and low expression of Galectin-۹ and TIM-۳ in leukemic cells (P=۰.۳۶۰ and P=۰.۶۵۵, respectively).Conclusion: Collectively, gene expression results suggest an important role for TIM-۳, but not VISTA and Galectin-۹, in B-ALL and it seems that TIM-۳ could be a candidate for immune checkpoint therapy.

کلیدواژه ها:

Acute lymphoblastic - leukemia ، Gelectin-۹ ، HAVCR۲ ، Immune checkpoint - receptor ، T-cell exhaustion ، TIM-۳ ، VISTA

نویسندگان

Armin Akbar

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Hossein asgariyan-Omran

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Reza Valadan

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Mohammad-Mehdi Dindarloo

Department of Biostatistics and Epidemiology, Mazandaran University of Medical Sciences, Sari, Iran

Ahmad Najafi

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Amir Kahrizi

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Arash Poursheikhani

Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran

Hossein Karami

Department of Hematology and Oncology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran

Mohammad Naderi

Department of Hematology and Oncology, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran

Shayan Sabeti

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Mohsen Tehrani

Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

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