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مقالات فارسیISIکنفرانسهاژورنالها

Scorpio and centipede ameliorate asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 12
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 60

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1797027

شناسه ملی سند علمی:

JR_IJBMS-26-12_008

تاریخ نمایه سازی: 7 آبان 1402

چکیده مقاله:

Objective(s):  We previously revealed that scorpio and centipede (SC) improve the inflammatory response in asthma, whereas it is unclear whether ferroptosis is involved in this process.Materials and Methods: The asthmatic mouse model was established and lung tissues were collected for histopathological examination. The levels of tumor necrosis factor-α (TNF-α), interleukin- (IL-)۱β, Fe۲+, malondialdehyde (MDA), glutathione peroxidase ۴ (GPX۴), ferritin heavy chain ۱(FTH۱), and reactive oxygen species (ROS) were assessed in asthmatic mice and mouse airway epithelial cells.Results: Our results showed that ferroptosis was induced in asthmatic mice, as evidenced by the reduction of FTH۱ and GPX۴ expression and the increase of MDA and Fe۲+ levels (all P<۰.۰۵). Ferrostatin-۱ repressed inflammation and ferroptosis of asthmatic mice. Additionally, SC significantly inhibited the levels of TNF-α, IL-۱β, MDA, and Fe۲+, while enhancing FTH۱ and GPX۴ expression. However, SC plus erastin showed the reverse results. Moreover, ferroptosis remarkably increased in asthmatic airway epithelial cells, while SC suppressed ferroptosis of the cells (all P<۰.۰۵).Conclusion: SC ameliorated asthma by inhibiting the crosstalk between ferroptosis and inflammation in airway epithelial cells.

کلیدواژه ها:

Airway epithelial cells ، Asthma ، Ferroptosis ، Inflammation ، Scorpio and centipede

نویسندگان

Yada Zhang

Department of Respiratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Yiren Chen

Department of Respiratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Yingen Wu

Department of Internal Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Ling Yang

Department of Geriatrics, Shanghai Fourth People’s Hospital Affiliated to Tongji University, Shanghai, China

Hong Fang

Prevention and Health Care Department of TCM, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Yanqi Cheng

Prevention and Health Care Department of TCM, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Yuqin Wu

Prevention and Health Care Department of TCM, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Binqing Tang

Department of Respiratory Medicine, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

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  • Murdoch JR, Lloyd CM. Chronic inflammation and asthma. Mutat Res ...
  • Xu J, Meng Y, Jia M, Jiang J, Yang Y, ...
  • GBD ۲۰۱۵ Chronic Respiratory Disease Collaborators. Global, regional, and national ...
  • van Brakel L, Mensink RP, Wesseling G, Plat J. Nutritional ...
  • Bianco A, Contoli M, Di Marco F, Saverio Mennini F, ...
  • Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, ...
  • Maslan J, Mims JW. What is asthma? Pathophysiology, demographics, and ...
  • Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, ...
  • Mao H, Zhao Y, Li H, Lei L. Ferroptosis as ...
  • Sun Y, Chen P, Zhai B, Zhang M, Xiang Y, ...
  • Li Y, Feng D, Wang Z, Zhao Y, Sun R, ...
  • Li C, Deng X, Xie X, Liu Y, Friedmann Angeli ...
  • Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad ...
  • Qi J, Kim JW, Zhou Z, Lim CW, Kim B. ...
  • Yao X, Sun K, Yu S, Luo J, Guo J, ...
  • Chen Y, Zhang P, Chen W, Chen G. Ferroptosis mediated ...
  • Bao C, Liu C, Liu Q, Hua L, Hu J, ...
  • Zeng Z, Huang H, Zhang J, Liu Y, Zhong W, ...
  • Wang P, Shang E, Fan X. Effect of San’ao decoction ...
  • Kyungjin L, Bumjung K, Youngmin B, Hyejin J, Meixiang S, ...
  • Liu DY, Zhao HM, Cheng SM, Rao Y, Huang XY, ...
  • Tang B, Shi K, Fang H, Wu Y. Clinical efficacy ...
  • Tang B, Wu Y, Fang H, Wu Y, Shi K. ...
  • Kianmeher M, Ghorani V, Boskabady MH. Animal model of asthma, ...
  • Liu P, Feng Y, Li H, Chen X, Wang G, ...
  • Li Y, Cao Y, Xiao J, Shang J, Tan Q, ...
  • Wang W, Yao Q, Teng F, Cui J, Dong J, ...
  • Jiao H, Yang H, Yan Z, Chen J, Xu M, ...
  • Luo L, Mo G, Huang D. Ferroptosis in hepatic ischemiareperfusion ...
  • Xu W, Deng H, Hu S, Zhang Y, Zheng L, ...
  • Wang Y, Liao S, Pan Z, Jiang S, Fan J, ...
  • Li J, Lu K, Sun F, Tan S, Zhang X, ...
  • Han F, Li S, Yang Y, Bai Z. Interleukin-۶ promotes ...
  • Lambrecht BN, Hammad H. The immunology of asthma. Nat Immunol ...
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  • Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. ...
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