The effect of silver nanoparticles of aqueous Matricaria chamomilla extract on acute liver toxicity caused by acetaminophen in mice

Objective: Attention to the daily prescription of large amounts of drugs by doctors; In recent years, much attention has been paid to the effect of plants in the treatment and prevention of drug poisoning. Matricaria chamomilla is one of the oldest medicinal plants known to man and its use dates back to ancient Greece. In this research, the protective effect of green tea extract in hepatotoxicity caused by acetaminophen has been investigated. Methods: So that ۴۸ adult male mice were randomly divided into ۶ groups. The control group received only physiological serum. The M. chamomile group received ۲۵۰ mg/kg and (AgNP)M chamomilla received ۰.۵ mg/kg for ۳۰ days. The acetaminophen group was prescribed ۵۰۰ mg/kg of acetaminophen orally, and the experimental groups (acetaminophen + M. chamomile extract) were given chamomile extract with a dose of ۲۵۰ mg/kg and (silver nanoparticle of M. chamomile plant + acetaminophen) (AgNP) M. chamomilla with a dose of ۰.۵ received mg/kg for ۳۰ days and a toxic dose of acetaminophen was prescribed on the ۲۹th day. Results: On the ۳۱st day, blood was drawn to measure alanine transferase (ALT) and aspartate transferase (AST), and after that, the animals' livers were placed in ۱۰% formalin for histopathological examination. The serum levels of ALT and AST enzymes in the silver nanoparticle group were significantly reduced compared to other groups. (P<۰.۰۵) so that in histopathological studies, liver necrosis, congestion of red blood cells and the accumulation of inflammatory cells in (AgNP) M. chamomilla were reduced compared to the acetaminophen group. Conclusion: According to the results of this research (AgNP)M chamomilla   is probably involved in liver necrosis caused by acetaminophen. It has a protective role.