The Effect of Resistance Training with Genistein on Interleukin-۶ and C- Reactive Protein in Induced Diabetic Rats
محل انتشار: مجله دیابت و چاقی ایران، دوره: 11، شماره: 1
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 67
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شناسه ملی سند علمی:
JR_IJDO-11-1_009
تاریخ نمایه سازی: 16 آبان 1402
چکیده مقاله:
Objective: The aim of this study was to investigate the effect of Resistance Training (RT) with Genistein on Interleukin-۶ (IL-۶) and C-reactive protein (CRP) in diabetic rats.
Materials and Methods: ۶۴ induced diabetic rats into ۸ groups were investigated with experimental study: first week control, last week control, RT, ۱۵ mg/kg Genistein consumption, resistance exercise with ۱۵ mg/kg Genistein consumption, ۳۰ mg/kg Genistein consumption, resistance exercise with ۳۰ mg/kg Genistein consumption and placebo (dimethyl sulfoxide). Rats in groups ۳, ۵ and ۷ performed ۸ weeks of RT with ۳۰ to ۱۰۰% of body weight in ۳ weekly sessions, and groups ۴, ۵, ۶, and ۷ received Genistein peritoneally with the mentioned doses. Also, to investigate the effects of diabetes induction on the study variables, ۱۶ healthy rats were selected and divided into two groups: healthy first week control and healthy last week control. The data were analyzed using independent sample T-tests, two-way and one-way ANOVA with Bonferroni’s post-hoc test in SPSS software (P-value≤ ۰.۰۵).
Results: RT had a significant effect on CRP reduction in induced diabetic rats (P-value≤ ۰.۰۵). Genistein consumption decreased IL- ۶ and CRP in diabetic rats (P-value≤ ۰.۰۵). Moreover, the interaction between RT and Genistein consumption had statistically significant effects on the reduction of IL-۶ and CRP in diabetic rats (P-value≤ ۰.۰۵); ۱۵ mg/kg Genistein consumption had a greater effect on the reduction of CRP than ۳۰ mg/kg Genistein consumption in induced diabetic rats (P-value≤ ۰.۰۵).
Conclusion: RT alone could not significantly reduce the levels of IL-۶ in induced diabetic rats; however, it seems that Genistein consumption with RT have interactive effects on reducing inflammatory factors in induced diabetic rats.
کلیدواژه ها:
نویسندگان
Saeed Ghodsbin
Department of Sport Physiology, Islamic Azad University– Larestan Branch, Larestan, Iran.
Sirous Farsi
Department of Sport Physiology, Islamic Azad University– Larestan Branch, Larestan, Iran.
Seyed Ali Hosseini
Department of Sport Physiology, Islamic Azad University– Marvdasht Branch, Marvdasht, Iran.
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