Impact of Phase Analysis of Gated SPECT to Assessment of Left Ventricular Mechanical Dyssynchrony in Diabetic Patients with Normal MPI

Objective: Diabetes mellitus is an important cause of heart failure deployment of left ventricular mechanical dyssynchrony. Nuclear cardiology phase analysis is an accurate, repeatable and reproducible modality for measurement LV dyssynchrony .The aim of study was assessment of phase analysis parameter including Standard deviation (SD) and band width (BW) in diabetic patient with normal MPI comparing with low risk population for CHD. Materials and Methods: An analytical cross-sectional study was performed in clinical research development unit of Farshchian heart center, Hamedan University of Medical Sciences. We evaluated ۱۶۵ patients who underwent SPECT MPI. Study population were ۹۰ diabetic patients with normal MPI (sss<۳) and ۷۵ health individuals without diabetes. Phase analysis parameters were compared in both groups using Quantitative Gated SPECT (QGS) software. Independent sample t-test and Pearson correlation test were used to compare the results. Results: The study results revealed no statistically significant differences in standard deviation (SD) and histogram band width (BW) of the phase analysis between diabetic patients and control group. Furthermore, in diabetic patient LVEF have a negative significant correlation to BW (r=-۰.۵۱۰) and SD (r=-۰.۴۲۲) but in control group there was no significant Pearson correlation is noticed. Conclusion: Between diabetic patients and low likelihood person for CHD with normal MPI phase analysis parameter (BW and SD) shows no significant difference.