Vitamin D and Training Modulates Gene Expression of TLR۴ and NFkB in Lung Tissue of Obese Rats in an Experimental Study
محل انتشار: مجله دیابت و چاقی ایران، دوره: 12، شماره: 1
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 64
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شناسه ملی سند علمی:
JR_IJDO-12-1_005
تاریخ نمایه سازی: 16 آبان 1402
چکیده مقاله:
Objective: Physical exercise has different effects on oxidative stress. Oxidative stress influences TLR۴ and NFkB gene expression. The purpose of this study was to investigate the effect of aerobic training and vitamin D on gene expression of TLR۴ and NFkB in lung tissue of obese rats exposed to oxygenated water.
Materials and Methods: In an experimental study, ۳۰ obese male wistar rats were randomly divided into five groups: control, oxygenated water, oxygenated water + vitamin D, oxygenated water + aerobic training, and oxygenated water + aerobic training + vitamin D. All the rats were injected intraperitoneally with oxygenated water. Vitamin D was performed by intraperitoneal injection of ۰.۵ μg daily for eight weeks. The aerobic training protocol included ۸ weeks, ۵ sessions per week running on treadmill. TLR۴ and NFkB gene expression of lung tissue were investigated using real time & PCR. Two-way ANOVA and Bonferroni post hoc test were used to analysis the data. The significant level was set at P-value< ۰.۰۵.
Results: Aerobic training significantly reduced TLR۴ expression compared with other groups (P-value: ۰.۰۴۶) but did not significantly affect the expression of NFkB gene (P-value: ۰.۲۶۱). Vitamin D alone and aerobic training and vitamin D interaction did not significantly alter the gene expression of TLR۴ (P-value: ۰.۰۷۲ and P-value: ۰.۶۹۵, respectively) and NFkB (P-value: ۰.۲۴۳ and P-value:< ۰.۱۹۵, respectively).
Conclusion: It seems that performing aerobic training is likely to be beneficial in reducing oxidative stress and inflammation compared to inactivity.
کلیدواژه ها:
نویسندگان
Milad Rahimi
PHD Candidate, Department of Exercise Physiology, Islamic Azad University, Central Branch, Tehran, Iran.
Mohammad Ali Azarbayjani
Full Professor, Department of Exercise Physiology, Islamic Azad University, Central Branch, Tehran, Iran.
Maghsoud Peeri
Full Professor, Department of Exercise Physiology, Islamic Azad University, Central Branch, Tehran, Iran.
Parvin Farzanegi
Associate Professor, Department of Exercise Physiology, Islamic Azad University, Sari Branch, Mazandaran, Iran.
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