Effects of ginger extract on smooth muscle activity of sheep reticulum and rumen
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 4، شماره: 2
سال انتشار: 1392
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 37
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شناسه ملی سند علمی:
JR_VRFAN-4-2_004
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Reticulorumen hypomotility leads to the impaired physiologic functions of the digestive tract. Prokinetic action of ginger has been demonstrated in the laboratory animals and human. The aim of this study was to evaluate the effect of hydroalcoholic extract of ginger on contraction and motility of reticulum and rumen of ruminants. Collected samples of reticulum and rumen from eight sheep were investigated in vitro. The extract at the concentration of ۰.۱ and ۱.۰ mg L-۱ had no effect on any preparations. Contraction of reticulum and rumen preparations was occurred at ۱۰.۰ and ۱۰۰ mg L-۱ concentrations (p < ۰.۰۵). Concentration of ۱۰۰۰ mg L-۱ caused a relaxation in preparations contracted with ۱۰.۰ and ۱۰۰ mg L-۱. Likewise, the concentration of ۱۰۰۰ mg L-۱ significantly (p < ۰.۰۵) inhibited ACh-induced contraction in both tissues. Six sheep were involved in electromyographic study. Administration of ۴۰ mg kg-۱ of the extract increased the overall frequency of contractions of the reticulum and rumen at the subsequent three days with the prominent increase at the second day (p < ۰.۰۵). Results of in vitro study indicated that hydroalcoholic extract of ginger contained spasmogenic and spasmolytic constituents. The results in vivo study represented evidences that the extract may have stimulant effect on reticulorumen motility in ۴۰ mg kg-۱ concentration.
کلیدواژه ها:
نویسندگان
Amin Mamaghani
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Masoud Maham
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Bahram Dalir-Naghadeh
Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran