Evaluation of Anti-ulcer Activity of Echinops Persicus on Experimental Gastric Ulcer Models in Rats

Extract of Echinops persicus is traditionally used for a long time in Iran for treatment of cough and constipation. This extract is produced by activity of bug (Situphilus spp.) on the plant. We documented its anti-tussive effect in rats in our previous study. The aim of this study was to assess the anti-ulcer effect of Echinops persicus in an animal model. In this study we evaluated anti-ulcer effect of Echinops persicus by Shay's method in rats. In ۳ groups of rats, pylorus was ligatured under anesthesia. The rats were euthanized after ۱۹ hours later and number and level of ulcer in stomach was measured. In group ۲ the extract was orally administered ۴۵ minutes before pyloric ligature, and in group ۳, it was administered intraperitoneally ۲۰ minutes before pyloric ligature. The number of ulcers in stomach was significantly low in group ۲ (P = ۰.۰۱) and ۳ (P = ۰.۰۳۷) in comparison with group ۱. The level of ulcer was significantly decreased in group ۲ (P = ۰.۰۴۷) with comparison to group ۱. We conclude that, Echinops extract can exhibit potentially cytoprotective and anti-ulcer activity.