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مقالات فارسیISIکنفرانسهاژورنالها

Anti-spermatogenic activities of Taraxacum officinale whole plant and leaves aqueous extracts

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 7، شماره: 2
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 50

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1818082

شناسه ملی سند علمی:

JR_VRFAN-7-2_001

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Taraxacum officinale has been used in Jordan folk medicine to treat male infertility. A recent study has proved a contradictory effect of the whole plant aqueous extract. The aim of the current study was to determine if the leaves of T. officinale have similar anti-fertility activities, and whether this effect is mediated through the regulation of spermatogonial stem cells (SSCs). Fifty adult male rats were divided into five groups. Two groups were gavaged with ۱/۱۰ of LD۵۰ of T. officinale whole plant (۱.۰۶ g kg-۱ body weight) or leaves (۲.۳۰ g kg-۱ body weight) aqueous extract; while two groups were gavaged with ۱/۲۰ of LD۵۰ of T. officinale whole plant (۲.۱۳ g kg-۱) or leaves (۴.۶۰ g kg-۱) extract. The control group received distilled water. Oral administration of T. officinale (whole plant and leaves aqueous extract) caused a significant decrease in testis and seminal vesicle weight, a reduction in serum testosterone concentration, impaired sperm parameters, and a decrease in pregnancy parameters. Testicular histology of treated rats showed structural changes such as hypoplasia of germ cells, reduction in the thickness of germinal epithelium, arrest of spermatogenesis at spermatid stage (late maturation arrest) and reduction in the number of Leydig cells. Gene expression levels of two SSCs markers (GFRα۱ and CSF۱) responsible for self-renewal were relatively counter-balanced. In conclusion, T. officinale whole plant and leaves aqueous extracts changed the gene expression of two SSCs markers leading to the imbalance between spermatogonia self-renewal and differentiation causing late maturation arrest.

کلیدواژه ها:

Dandelion ، Maturation arrest ، Rat ، Renewal ، Spermatogenesis

نویسندگان

Lubna Tahtamouni

Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan

Rema Al-Khateeb

Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan

Reem Abdellatif

Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan

Zainab Al-Mazaydeh

Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan

Salem Yasin

Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan

Samer Al-Gharabli

Department of Pharmaceutical and Chemical Engineering, School of Applied Medical Sciences, German Jordanian University, Amman, Jordan

Ali Elkarmi

Department of Biology and Biotechnology, Faculty of Science, The Hashemite University, Zarqa, Jordan

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  • Kretser DM, Loveland KL, Meinhardt A, et al. Spermatogenesis. Hum ...
  • Sadri-Ardekani H, Mizrak SC, van Daalen SK, et al. Propagation of human spermatogonial ...
  • Nayernia K, Li M, Engel W. Spermatogonial stem cells. Methods ...
  • de Rooij DG, Russell LD. All you wanted to know ...
  • Ferguson L, How JJ, Agoulnik AL. The fate of spermatogonial ...
  • Hofmann MC. Gdnf signaling pathways within the mammalian spermatogonial stem ...
  • Fouchécourt S, Godet M, Sabido O, et al. Glial cell-line-derived neurotropic factor and ...
  • Kokkinaki M, Lee TL, He Z, et al. Age affects ...
  • Payne CJ. Cycling to and from a stem cell niche: ...
  • Ketkar A, Reddy K. Expression pattern of OCT-۴ and PLZF ...
  • Orlu E, Ogbalu O. Partial inhibitory effect of ethanol extract ...
  • Tahtamouni LH, Alqurna N, Al Hudhud MY, et al. Dandelion ...
  • World Health Organization. WHO protocol MB-۵۰, a method for examining ...
  • Sigstedt SC, Hooten CJ, Callewaert MC, et al. Evaluation of ...
  • Revathi P, Vani B, Sarathchandiran I, et al. Reproductive toxicity ...
  • Oyewopo A, Oremosu A, Akang E, et al. Effects of ...
  • Jia F, Sun Z, Yan X, et al. Effect of ...
  • Tejada RI, Mitchell JC, Norman A, et al. Test for ...
  • Sambrook J, Fritsch EF, Maniatis T. Molecular cloning, a laboratory ...
  • Morimoto H, Kanatsu-Shinohara M, Takashima S, et al. Phenotypic plasticity ...
  • Peinnequin A, Mouret C, Birot O, et al. Rat pro-inflammatory ...
  • Schütz K, Carle R, Schieber A. Taraxacum: A review on ...
  • Takzare N, Hosseini MJ, Mortazavi S, et al. The effect ...
  • Dorsch W. Clinical application of extracts of Echinacea purpurea or ...
  • Choi UK, Lee OH, Yim JH, et al. Hypolipidemic and ...
  • Yakubu MT. Effect of a ۶۰-day oral gavage of a ...
  • Russell LD, Clermont Y. Degeneration of germ cells in normal, ...
  • Bartoov B, Eltes F, Pansky M, et al. Estimating fertility ...
  • Agarwal M, Sharma P,Kushwaha S. Antifertillty efficacy of ۵۰% ethanolic ...
  • Kolasa A, Misiakiewicz K, Marchlewicz M, et al. The generation ...
  • Padashetty SA, Mishra SH. Effect of terpenoidal fraction of Echinops ...
  • Zhou Q, Griswold MD. Regulation of spermatogonia. Available at: http://www.stembook.org/node/۴۵۷.html. ...
  • Singh SR, Burnicka-Turek O, Chauhan C, et al. Spermatogonial stem ...
  • Costoya JA, Hobbs RM, Barna M, et al. Essential role ...
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