Large B-cell lymphoma in a dog: A cyto-histopathological evaluation and Immunophenotyping according to WHO classification for canine lymphomas
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 7، شماره: 1
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 55
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شناسه ملی سند علمی:
JR_VRFAN-7-1_013
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
In the present study, we described cyto-histopathological features and immunophenotyping of the large B-cell lymphoma in an ۸-year-old mixed breed dog with applying the World Health Organization (WHO) system of classification of canine lymphomas. In fine-needle aspiration (FNA), lymph nodes were involved by neoplastic cells of intermediate to large size with deep blue cytoplasm; consist of centroblasts, immunoblast and medium-sized cells. Histopathologically, the follicles and sinuses of lymph nodes were replaced by sheets of numerous immunoblasts (less than ۹۰.۰% of total cells) and centroblasts. Numerous mitotic figures were also observed. Immunohistochemical analysis presented that the neoplastic cells express B-cell phenotype CD۲۰ and CD۷۹a, but do not stain for T phenotype CD۳. On the basis of cytology, histopathology and immunohistochemical findings, the present tumor was diagnosed as diffuse large B-cell lymphoma, high-grade centroblastic type (DLBCL-CB) according to WHO histological classification. Applying this classification system for diagnosis of canine lymphomas is very useful and has a high accuracy and consistency. However, further co-operative studies between clinicians and pathologists should be performed, in order to improve the effectiveness of this classification.
کلیدواژه ها:
نویسندگان
Zahra Nikousefat
Department of Clinical Sciences, School of Veterinary Medicine, Razi University, Kermanshah, Iran
Mohammad Hashemnia
Department of Pathobiology, School of Veterinary Medicine, Razi University, Kermanshah, Iran
Moosa Javdani
Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
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