The effects of pomegranate extract on normal adult rat kidney: A stereological study
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 7، شماره: 1
سال انتشار: 1395
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 68
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شناسه ملی سند علمی:
JR_VRFAN-7-1_001
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Pomegranate (Punica granatum L.) has been used widely in the traditional medicine of various civilizations for more than ۵۰۰۰ years. The pomegranate tree has several parts; each part has useful medicinal effects. Previous studies have demonstrated the antibacterial, antioxidant, and anti-inflammatory properties of pomegranate. The aim of the present study was to determine whether administration of pomegranate extract could result in morphometric changes in the kidneys of rats. Eighteen male rats (۱۸۰-۲۰۰ g) were divided into three groups that received either: G۱, distilled water; G۲, ۲۵۰ mg kg-۱ pomegranate extract; and G۳, ۵۰۰ mg kg-۱ pomegranate extract via oral gavages daily for eight weeks. At the end of eight weeks, the rats were euthanized and their kidneys were removed and processed for morphometric analyses. In rats received pomegranate extract, the kidney weight, kidney weight/body weight ratio, cortex volume and glomerular volume were increased (p < ۰.۰۵), while, medulla volume and the number of glomeruli per kidney did not change. No pathological lesions were observed in the kidney. Therefore, pomegranate hydro-alcoholic extract at doses of ۲۵۰ and ۵۰۰ (mg kg-۱) increased the volume of some parts of the kidney; however, it did not cause any pathological changes in the kidney.
کلیدواژه ها:
نویسندگان
Esrafil Mansouri
Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
John Basgen
Life Sciences Institute, Charles R. Drew University of Medicine and Science, Los Angeles, USA
Sadegh Saremy
Department of Anatomical Sciences, Cellular and Molecular Research Center, Faculty of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
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