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مقالات فارسیISIکنفرانسهاژورنالها

Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 5، شماره: 2
سال انتشار: 1393
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 48

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https://civilica.com/doc/1818161

شناسه ملی سند علمی:

JR_VRFAN-5-2_007

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Hydrogen Sulfide (H۲S) prevents and treats a variety of disorders via its cytoprotective effects. However, the effects of H۲S on rats with cisplatin (CP) nephrotoxicity are unclear. The aim was to study the effects of H۲S on rats with CP nephrotoxicity. Thirty male Sprague-Dawley rats were divided into three groups: control group, nephrotoxic group received single dose of CP (۶ mg kg-۱) and nephrotoxic groups that received single dose ۱۰۰ µmol kg-۱ NaHS. On fifth day after injection, urine of each rat was collected over a ۲۴-hr period. Animals were sacrificed ۶ days after CP (or vehicle) treatment, and blood, urine, and kidneys were obtained, prepared for light microscopy evaluation, lipid peroxidation content and laboratory analysis. The results showed that plasma urea (۲۲۶%), creatinine (۲۷۱%), renal lipid peroxidation content (۱۵۱%), Na and K fractional excretion, urine protein, volume and kidney weight in CP nephrotoxic rats were significantly higher and urine osmolarity and creatinine clearance lower than in controls. Increases of the proximal tubular cells apoptosis and mesangial matrix in CP nephrotoxicity group rats were observed. Hydrogen sulfide reversed the CP-induced changes in the experimental rats H۲S prevented the progression of CP nephrotoxicity in rats possibly through its cytoprotective effects such as antioxidant properties.

کلیدواژه ها:

Apoptosis ، cisplatin ، Hydrogen Sulfide ، Nephrotoxicity

نویسندگان

Akram Ahangarpour

Department of Physiology and Physiology Research Center, School of Medicine, Jundishapur University of Medical Sciences of Ahvaz, Ahvaz, Iran

Amin Abdollahzade Fard

Department of Physiology and Physiology Research Center, School of Medicine, Jundishapur University of Medical Sciences of Ahvaz, Ahvaz, Iran

Mohammad Kazem Gharibnaseri

Department of Physiology and Physiology Research Center, School of Medicine, Jundishapur University of Medical Sciences of Ahvaz, Ahvaz, Iran

Taha Jalali

Department of Physiology and Physiology Research Center, School of Paramedicine, Jundishapur University of Medical Sciences of Ahvaz, Ahvaz, Iran

Iran Rashidi

Department of Pathology, Shafa Hospital, Ahvaz, Iran

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