Effect of chlorpyrifos on sperm characteristics and testicular tissue changes in adult male rats

سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 56

فایل این مقاله در 8 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

JR_VRFAN-8-4_008

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Chlorpyrifos (CPF) is a broad spectrum organophosphate pesticide used for agricultural health purposes. Its principal mechanism of toxicity is the inhibition of acetylcholinesterase. The purpose of present study was to investigate the effects of CPF on testicular tissue and sperm parameters in male rats. Thirty-two healthy male rats were divided into two groups: a CPF-exposed group and a control-sham group. Control-sham group received corn oil (۰.۲۰ mL per day). The CPF was administered orally to male rats at ۳۷ mg kg-۱ BW for ۴۵ days to evaluate the reproductive toxicity. In all rats, sampling for histological and sperm analyses was performed on days ۵, ۱۵, ۳۰ and ۴۵. The CPF caused a significant (p < ۰.۰۵) decrease in sperm count, viability and motility and increased immature sperms and DNA damage in sperm cells. Light microscopic analyses revealed increased arrested spermatogenesis, negative tubular differentiation and repopulation indexes and decreased Leydig cells number. These findings indicate that CPF has adverse effects on sperm cells and reproductive system of male rats.

کلیدواژه ها:

نویسندگان

Mojtaba Babazadeh

Graduate Student, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Gholamreza Najafi

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Xavier R, Rekha K, Bairy KL. Health perspective of pesticide ...
  • Peiris-John RJ, Wickremasinghe R. Impact of low-level exposure to organophosphate ...
  • Muñoz-Quezada MT, Lucero BA, Iglesias VP, et al. Chronic exposure ...
  • Eaton DL, Daroff RB, Autrup H, et al. Review of ...
  • Ambali SF, Akanbi DO, Oladipo OO, et al. Subchronic chlorpyrifos ...
  • Uchendu C, Ambali SF, Ayo JO, et al. Subacute chlorpyrifos-induced ...
  • Joshi CS, Mathur R, Gulati N. Testicular toxicity of chlorpyrifos ...
  • Jalali AS, Hasanzadeh S, Malekinejad H. Crataegus monogyna aqueous extract ...
  • Shetty G, Wilson G, Huhtaniemi I, et al. Gonadotropin releasing ...
  • Rezvanfar MA, Sadrkhanlou RA, Ahmadi A, et al. Protection of ...
  • Suzuli N, Sofikitis N. Protective effects of antioxidants on testicular ...
  • Hosseinchi M, Soltanalinejad F, Najafi G, et al. Effect of gibberellic ...
  • Zambrano E, Rodriguez-Gonzalez GL, Guzman C, et al. A maternal ...
  • Wyrobek AJ, Gordon LA, Burkhart JG, et al. An evaluation ...
  • Wong A, Chuan SS, Patton WC, et al. Addition of ...
  • Tejada RI, Mitchell JC, Norman A, et al. A test for the practical ...
  • David JG. Toxicity of imidacloprid to Galendromus occidentalis, Neoseiulus fallacis ...
  • Yurumez Y, Durukan P, Yavuz Y, et al. Acute organo-phosphate ...
  • Rotenberg M, Shefi M, Dany S, et al. Differentiation between ...
  • Bo L. Therapeutic efficacies of different hemoperfusion frequencies in patients ...
  • Deacon MM, Murray JS, Pilny MK, et al. Embryotoxicity and ...
  • Breslin WJ, Liberacki AB, Dittenber DA, et al. Evaluation of ...
  • Moser VC. Comparisons of the acute effects of cholinesterase inhibitors ...
  • Corley RA, Calhoun LL, Dittenber DA, et al. Chlorpyrifos: A۱۳-week ...
  • Sujatha R, Chitra K, Latchoumycandane C, et al. Effect of ...
  • Rahman MF, Mahboob M, Danadevi K, et al. Assessment of ...
  • Harfod AJ, Halloran K, Wright PFA. The effects of in ...
  • Verma RS, Mehta A, Srivastava N. In vivo chlorpyrifos induced ...
  • Ahmed NS, Mohamed AS, Abdel-Wahhab MA. Chlorpyrifos-induced oxidative stress and ...
  • Thrasher JD, Madison R, Broughton A. Immunologic abnormalities in humans ...
  • Gupta SC, Siddique HR, Mathur N, et al. Adverse effect ...
  • Trasher JD, Heuser G, Broughton A. Immunological abnormalities in human ...
  • Goel A, Dani V, Dhawan DK. Protective effects of zinc ...
  • Jett DA, Navoa RV. In vitro and in vivo effects ...
  • Ishii N, Senoo-Matsuda N, Miyake K, et al. Coenzyme Q۱۰ ...
  • Joshi CS, Mathur R, Gulati N. Testicular toxicity of chlorpyrifos ...
  • Dwivedi PD, Das M, Khanna SK. Role of cytochrome P۴۵۰ ...
  • de Lamirande E, Jiang H, Zini A, et al. Reactive ...
  • Sikka SC. Relative impact of oxidative stress on male reproductive ...
  • Ferdinand N, Pierre W, Augustave K, et al. Effect of ...
  • Farag AT, Ahmed F, Aswad E, et al. Assessment of ...
  • Sayym F. Histopathological effects of dimethoate on testes of rats. ...
  • نمایش کامل مراجع