Ameliorative effects of Achillea millefolium inflorescences alcoholic extract on nicotine-induced reproductive toxicity in male rat: Apoptotic and biochemical evidences
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 8، شماره: 2
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 63
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شناسه ملی سند علمی:
JR_VRFAN-8-2_002
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Nicotine (NIC) adversely influences male reproductive system. Achillea millefolium (Achm) as a medicinal plant is highly regarded for its antioxidant and anti-inflammatory properties. The present study was conducted to assess whether Achminflorescences alcoholic extract could serve as a protective agent against reproductive toxicity in NIC-exposed male rats. Adult male rats were randomly divided into six groups. Two groups received NIC at doses of ۰.۲۰ and ۰.۴۰ mg kg-۱ per day in ۰.۵۰ mL sterile distilled water for ۴۸ days intraperitoneally, respectively. The further two groups received NIC at doses of ۰.۲۰ and ۰.۴۰ mg kg-۱ per day in ۰.۵۰ mL sterile distilled water for intraperitoneally along with Achm extract at a dose of ۱.۲۰ g kg-۱ per day in ۱ mL sterile distilled water orally for ۴۸ days, respectively. A vehicle treated control group and an Achm-only treated group were also included. The NIC-exposed groups showed significant reductions in epididymal sperm count, motility, viability and serum levels of FSH, LH and testosterone as well as testicular antioxidant capacity. Moreover, the incidence of apoptosis and abnormality in spermatozoa along with testicular malondialdehyde and total nitrite levels were significantly higher in NIC-treated rats. The above-mentioned parameters were restored to near normal levels by Achm co-administration. These findings indicated thatAchmmay partially be protective against NIC-induced testicular toxicity.
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نویسندگان
Ameneh Hasanzadeh Khosh
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Shapour Hasanzadeh
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Ali Shalizar Jalali
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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