ورود
مقالات فارسیISIکنفرانسهاژورنالها

Changes in the expression of OCT۴ in mouse ovary during estrous cycle

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 8، شماره: 1
سال انتشار: 1396
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 58

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1818260

شناسه ملی سند علمی:

JR_VRFAN-8-1_007

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

The transcriptional factor OCT۴ regulates pluripotency of stem cells and has an important role during oocyte growth. Whereas, its role has remained ambiguous in ovarian tissue during reproductive cycle. Therefore, this study was aimed to investigate the expression patterns of OCT۴ in mouse ovaries during the normal estrous cycle. Adult National Medical Research Institute mice were classified as proestrous, estrous, metestrous and diestrous on the basis of vaginal smear cytology. Their ovaries were removed and the protein and gene expression levels of OCT۴ were assessed using immunohistochemical staining and real-time quantitative reverse-transcription PCR, respectively. Immunohistochemical staining revealed the expression of OCT۴ in the cytoplasm of corpus luteum cells. In the follicles, OCT۴ was expressed in the cytoplasm of granulosa cells. Furthermore, the gene expression levels of OCT۴ was significantly higher in the proestrous phase than in the other phases of the estrous cycle (p < ۰.۰۵). The results indicated that OCT۴ gene expression levels are affected by the cyclic pattern of the estrous cycle.

کلیدواژه ها:

Estrous cycle ، Expression ، Mouse ، OCT۴ ، Ovarian tissue

نویسندگان

Narges Bagheripour

Department of Cellular and Molecular Biology, School of Biology, Damghan University, Damghan, Iran

Saeed Zavareh

Department of Cellular and Molecular Biology, School of Biology, Damghan University, Damghan, Iran

Mohammad Taghi Ghorbanian

Department of Cellular and Molecular Biology, School of Biology, Damghan University, Damghan, Iran

Seyed Hassan Paylakhi

Department of Cellular and Molecular Biology, School of Biology, Damghan University, Damghan, Iran

Seyed Reza Mohebbi

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Virant-Klun I, Stimpfel M, Skutella T. Stem cells in adult ...
  • Monti M, Garagna S, Redi C, et al. Gonadotropins affect ...
  • Richards JS. Hormonal control of gene expression in the ovary. ...
  • Gilchrist R, Ritter L, Armstrong D. Oocyte–somatic cell interactions during ...
  • Pangas SA, Rajkovic A. Transcriptional regulation of early oogenesis: In ...
  • Rajkovic A, Pangas SA, Ballow D, et al. NOBOX deficiency ...
  • Préfontaine GG, Walther R, Giffin W, et al. Selective binding ...
  • Brehm A, Ohbo K, Scholer H. The carboxy-terminal transactivation domain ...
  • Kehler J, Tolkunova E, Koschorz B, et al. OCT۴ is ...
  • Rani CS, Moudgal N. Examination of the role of FSH ...
  • Bhartiya D, Parte S, Patel H, et al. Novel action ...
  • Hartiya D, Sriraman K, Gunjal P, et al. Gonadotropin treatment ...
  • Patel H, Bhartiya D, Parte S, et al. Follicle stimulating ...
  • Singletary SJ, Kirsch AJ, Watson J, et al. Lack of ...
  • Park IH, Zhao R, West JA, et al. Reprogramming of ...
  • Pesce M, Wang X, Wolgemuth DJ, et al. Differential expression ...
  • Zuccotti M, Merico V, Sacchi L, et al. Oct-۴ regulates ...
  • McLean AC, Valenzuela N, Fai S, et al. Performing vaginal ...
  • Zhang Z, Zhu Y, Lai Y, et al. Follicle-stimulating hormone ...
  • Zou K, Yuan Z, Yang Z, et al. Production of ...
  • Varras M, Griva T, Kalles V, et al. Markers of ...
  • Wang X, Dai J. Concise review: Isoforms of OCT۴ contribute ...
    • نمایش کامل مراجع