The Importance of Other HPV in High-Grade CIN

Background & Objective: High-risk (HR) HPV infection is the major cause of cervical cancer, which is still one of the most common cancers among women. Based on some not-published results, it seems that some of the other HR HPVs might be as important as HPV ۱۶, and ۱۸ in developing high-grade CIN. This study was conducted to determine the relationship between Other HPV and high-grade CIN.Materials & Methods: In this prospective study from ۲۰۱۹ to ۲۰۲۲ (approved by the ethics committee), all women with positive HPV based on the COBAS method were invited to participate in the study (N=۶۴۶). For all the patients, colposcopy was done, and then the liquid-based samples of women with Other HPV positives were reanalyzed by HPV typing.Results: All the patients who were infected with HPV۱۸ were involved in CIN۱. On the other hand, ۵۰% of patients who were infected with HPV۱۸ were involved in CIN۲. ۵۰% of patients with HPV۴۵ were involved in CIN۲. There is also a significant relationship between HPV۳۱ and CIN۳.Conclusion: Because in our study there was a significant relationship between CIN۳ and HPV۳۱; and CIN۲ with HPV۴۵, and in the COBAS method, HPV۳۱ and HPV۴۵ are only reported under the general title of Other HPV, because of the possibility of the importance of other HPV with high-grade neoplasias, it is recommended to analyze the other HPV with HPV typing. Further studies are needed to confirm our findings.