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Irradiated oocysts in combination with inulin adjuvant-induced potent immune responses against Eimeria tenella infection in broiler chickens

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 14، شماره: 8
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 64

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https://civilica.com/doc/1818443

شناسه ملی سند علمی:

JR_VRFAN-14-8_003

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Coccidiosis is the leading parasitic disease in poultry. One of the most critical Eimeria species, Eimeria tenella, lives inside the cecal epithelial cells and induces bloody coccidiosis. The present study evaluated the effect of radiation-attenuated E. tenella oocytes mixed with inulin adjuvant on broiler chicken. Initially, the effect of irradiation on oocyst attenuation was confirmed. Then, one-day-old broilers (n = ۹۰) were divided into nine groups on seven days of age as follow: Group ۱ (۴۰۰ attenuated oocysts + ۱.۰۰ mg of adjuvant), group ۲ (۴۰۰ attenuated oocysts + ۰.۵۰ mg adjuvant), group ۳ (۲۰۰ attenuated oocysts + ۱.۰۰ mg of adjuvant), group ۴ (۲۰۰ attenuated oocysts + ۰.۵۰ mg adjuvant), group ۵ (۱.۰۰ mg adjuvant), group ۶ (۴۰۰ attenuated oocysts), group ۷ (commercial vaccine), group ۸ (negative control) and group ۹ (blank). On day ۲۱, we performed a challenge with E. tenella oocytes and investigated oocyst output and average weekly weight throughout the study. At the end of the study, we evaluated macroscopic lesion, histology, cytokine level and leukogram status. The results showed a statistically significant difference among groups. Furthermore, the optimal dose was ۴۰۰ irradiated oocysts and ۱.۰۰ mg of inulin. Moreover, an X-ray could reduce the virulence of E. tenella oocytes. Inulin alone or combined with attenuated oocysts showed an acceptable effect on evaluated parameters.

کلیدواژه ها:

Broiler ، Eimeria tenella ، Inulin ، X-ray

نویسندگان

Monireh Falsafi

Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Nowruz Delirezh

Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Elham Safarzadeh

Department of Medical Microbiology, Parasitology and Immunology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

Alireza Talebi

Department of Poultry Health and Diseases, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Zahra Heidari

Department of Medical Microbiology, Parasitology and Immunology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran

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