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مقالات فارسیISIکنفرانسهاژورنالها

The effects of exposure to fluoxetine during lactation on testicular tissue and sperm parameters in mice offspring

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 11، شماره: 1
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 55

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https://civilica.com/doc/1818557

شناسه ملی سند علمی:

JR_VRFAN-11-1_006

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Fluoxetine is a selective serotonin reuptake inhibitor is commonly prescribed to treat maternal depression in pregnancy and lactation. This study aimed to investigate the effects of maternal exposure to fluoxetine via lactation on testicular tissue, sperm parameters including count, motility, viability, and normal morphology and testicular oxidative stress status in male mice offspring. Ten mice dams were divided into control and experimental groups. The control group received water and the experimental group received fluoxetine (۲۰ mg kg-۱) by gavage daily from postnatal days of ۰-۲۱. Histology of testis, sperm parameters and oxidative stress in the testicular tissue were analyzed at ۸۰ days after birth in their male offspring (n = ۸). Significant reductions in the body and testes weights were observed in animals exposed to fluoxetine. Additionally, fluoxetine exposure significantly reduced all sperm parameters, tubular diameter and epithelial height of the seminiferous tubules as well as Leydig cells number. Significant increases in the testicular malondialdehyde levels and percentage of sperm with chromatin/DNA damage were observed in mice exposed to fluoxetine compared to control. These findings suggest that maternal exposure to fluoxetine during lactation in mice has a negative effect on the testicular tissue of their offspring and impairs the spermatogenesis process which in turn can induce infertility.

کلیدواژه ها:

Fluoxetine ، Mice ، Sperm parameter ، Testis

نویسندگان

Mojtaba Karimi pour

Department of Anatomy and Histology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Abbas Ahmadi

Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

Masoumeh Zirak Javanmard

Department of Anatomy and Histology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Abass Jafari

Department of Occupational Health, School of Health, Urmia University of Medical Sciences, Urmia, Iran

Maryam Mohebi

Department of Anatomy and Histology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Elnaz Hosseinalipour

Department of Anatomy and Histology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

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  • de Oliveira WM, de Sá IR, de Torres SM, et ...
  • Monteiro Filho WO, Torres SMD, Amorim MJAAL, et al. Fluoxetine ...
  • Kim J, Riggs KW, Misri S, et al. Stereoselective disposition ...
  • Cornish AM, McMahon CA, Ungerer JA, et al. Postnatal depression ...
  • Leung BM, Kaplan BJ. Perinatal depression: Prevalence, risks, and the ...
  • Cohen LS, Wang B, Nonacs R, et al. Treatment of ...
  • Murray L, Fiori‐Cowley A, Hooper R, et al. The impact ...
  • Poobalan AS, Aucott LS, Ross L, et al. Effects of ...
  • Erdemir F, Atilgan D, Firat F, et al. The effect ...
  • Ververs T, Kaasenbrood H, Visser G, et al. Prevalence and ...
  • Kristensen J, Ilett K, Hackett L, et al. Distribution and ...
  • Carrasco J, Sandner C. Clinical effects of pharma-cological variations in ...
  • Mulder EJ, Ververs FF, De Heus R, et al. Selective ...
  • Oberlander TF, Warburton W, Misri S, et al. Neonatal outcomes ...
  • Pawluski JL, Rayen I, Niessen NA, et al. Developmental fluoxetine ...
  • Safarinejad MR. Evaluation of endocrine profile and hypothalamic-pituitary-testis axis in ...
  • Harris SS, Maciag D, Simpson KL, et al. Dose-dependent effects ...
  • Müller JC, Boareto AC, Lourenço EL, et al. In utero ...
  • Bataineh HN, Daradka T. Effects of long-term use of fluoxetine ...
  • Naumenko E, Shishkina G. Role of serotonin in feedback control ...
  • Zhang H, Wang H, Ji Y-L, et al. Lactational fenvalerate ...
  • Narayana K, Verghese S, Jacob SS. L-Ascorbic acid partially protects ...
  • World Health Organization. Laboratory manual of the WHO for the ...
  • Agarwal A, Makker K, Sharma R. Clinical relevance of oxidative ...
  • Wyrobek AJ, Gordon LA, Burkhart JG, et al. An evaluation ...
  • Narayana K, D’Souza UJ, Rao KS. Ribavirin-induced sperm shape abnormalities ...
  • Talebi AR, Sarcheshmeh AA, Khalili MA, et al. Effects of ...
  • Hu M-L. Measurement of protein thiol groups and glutathione in ...
  • Jafari A, Rasmi Y, Hajaghazadeh M, et al. Hepato-protective effect ...
  • Jafari A, Baghaei A, Solgi R, et al. An electro-cardiographic, ...
  • Morrison JL, Riggs KW, Rurak DW. Fluoxetine during pregnancy: Impact ...
  • McGuirk J, Silverstone T. The effect of the ۵-HT re-uptake ...
  • Silva J, Lins A, Amorim J, et al. Neonatal administration ...
  • França LR, Avelar GF, Almeida FF. Spermatogenesis and sperm transit ...
  • França LR, Silva Jr VA, Chiarini-Garcia H, et al. Cell ...
  • Aggarwal A, Jethani SL, Rohatgi RK, et al. Effects of ...
  • Vieira ML, Hamada RY, Gonzaga NI, et al. Could maternal ...
  • Ramos AC, dos Santos AH, Silveira KM, et al. Maternal ...
  • Zhengwei Y, Wreford NG, de Kretser DM. A quantitative study ...
  • Hooley R, Paterson M, Brown P, et al. Intra-testicular injection ...
  • Orth JM, Gunsalus GL, Lamperti AA. Evidence from Sertoli cell-depleted ...
  • Alzahrani H. Sister chromatid exchanges and sperm abnormalities produced by ...
  • Kumar VS, Sharma VL, Tiwari P, et al. The spermicidal ...
  • Orth JM. Cell biology of testicular development. In: Desjardins C, ...
  • Angulo C, Maldonado R, Pulgar E, et al. Vitamin C ...
  • Shinohara T, Orwig KE, Avarbock MR, et al. Restoration of ...
  • Hadi N, Singh S, Ahmad A, et al. Strand scission ...
  • Razi M, Malekinejad H, Sayrafi R, et al. Adverse effects ...
  • Sikka SC. Relative impact of oxidative stress on male reproductive ...
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