Protective effect of ethyl pyruvate on testicular histology and fertilization potential in cyclophosphamide treated mice
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 11، شماره: 1
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 51
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شناسه ملی سند علمی:
JR_VRFAN-11-1_002
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
In the present study, we aimed to address the use of ethyl pyruvate (EP) against the harmful effects of cyclophosphamide (CP) treatment. Thirty-nine adult male mice were divided into three groups including control group received normal saline [۰.۲۰ mL per day; intraperitoneally (IP)], CP group received CP (۱۵.۰۰ mg kg-۱ per week, IP) and CP+EP group received EP (۴۰.۰۰ mg kg-۱ per day, IP) along with CP and treated for ۳۵ days. After preparation of paraffin sections and Hematoxylin and Eosin staining, the histomorphometric studies were performed on the testicular tissue. Additionally, the serum superoxide dismutase (SOD) and testosterone level, testis malondialdehyde (MDA) and in vitro fertilization rate were assessed. The results showed an increase in the tubal differentiation index, repopulation index, spermiogenesis index, thickness of testicular capsule, mean distribution of active Sertoli cells, SOD and testosterone levels of the CP+EP group in comparison with the CP group. Moreover, the MDA levels in the CP+EP group were lower than the CP group. An increase occurred in the percentage of fertilization in the CP+EP group compared to the CP group. Results of this study revealed that the EP ameliorates deleterious side effects of CP on testicular histology and in vitro fertility.
کلیدواژه ها:
نویسندگان
Zahra Bakhtiary
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Rasoul Shahrooz
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Abbas Ahmadi
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Farhad Soltanalinejad
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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