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مقالات فارسیISIکنفرانسهاژورنالها

Effects of pentoxifylline and alendronate on fracture healing in ovariectomy-induced osteoporosis in rats

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 10، شماره: 2
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 61

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لینک ثابت به این مقاله:
https://civilica.com/doc/1818590

شناسه ملی سند علمی:

JR_VRFAN-10-2_001

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Osteoporosis is determined by decreased bone strength that increases the threat of fractures. The aim of this study was to evaluate the effects of pentoxifylline (PTX) and alendronate (ALN), on the stereological parameters, and gene expression in callus of fracture in an experimental rat model of ovariectomy-induced osteoporosis (OVX). The OVX was induced in ۹۰ female rats. Fourteen weeks later, a complete fracture on the right femur was made. Rats were divided into five groups: ۱) control: no treatment; ۲) sham: received daily distilled water; ۳) daily ۳.۰۰ mg kg-۱ ALN subcutaneously (SC); ۴) daily ۲۰۰ mg kg-۱ PTX (SC) and ۵) daily PTX (SC) + ALN (same doses). The osteoclast count was significantly lower in all treatment groups, at ۲۱ and ۵۶ days post-surgery, compared to the control and sham groups. The PTX significantly increased total callus volume at ۲۱ and ۵۶ days post-surgery, compared to the other groups. The PTX+ALN treatment significantly increased both cortical bone volume on day ۲۱, and osteocyte and osteoblast numbers on day ۵۶, compared to the control and sham groups. It can be concluded that PTX and ALN have antiresorptive effects, in OVX rats. Also, PTX has increased the extracellular matrix on both ۲۱ and ۵۶ days after surgery, compared to the other groups. PTX+ALN elevated cortical bone volume on day ۲۱, and osteocyte and osteoblast numbers compared to the control and sham groups on day ۵۶.

کلیدواژه ها:

Fracture healing ، osteoporosis ، Ovariectomy ، Real time PCR ، Stereology

نویسندگان

Mohammad Mahdi Vashghani Farahani

Department of Basic Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Reza Farahani

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

Mohammad-Amin Abdollahifar

Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

Mahdi Ghatrehsamani

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Seyed Kamran Ghoreishi

Department of Statistics, Faculty of Sciences, University of Qom, Qom, Iran

Behnam Hajihossainlou

Department of Internal Medicine, Aurora Medical Center- Bay Area, Marinette, Wisconsin, USA

Sufan Chien

Price Institute of Surgical Research, University of Louisville, Noveratech LLC of Louisville, Louisville, USA

Atarodsadat Mostafavinia

Department of Anatomy, School of Medicine, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Fatemehalsadat Rezaei

Cellular and Molecular Biology Research Center, Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran

Mohammad Bayat

Cellular and Molecular Biology Research Center, Department of Biology and Anatomical Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran

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