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Protective effects of Nigella sativa on synaptic plasticity impairment induced ‎by lipopolysaccharide

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 9، شماره: 1
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 72

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لینک ثابت به این مقاله:
https://civilica.com/doc/1818628

شناسه ملی سند علمی:

JR_VRFAN-9-1_005

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

In the present study the protective effect of Nigella sativa (N. sativa)on synaptic plasticity impairment induced by lipopolysaccharide (LPS) in rats was investigated. Fifty-eight rats were grouped and treated as follows: ۱) control (saline), ۲) LPS, ۳) LPS-N. sativa,and ۴) N. sativa. In a Morris water maze test, the escape latency and traveled path to find the platform as well as time spent and the traveled distance in target quadrant (Q۱) were measured. Long term potentiation (LTP) from CA۱ area of hippocampus followed by high frequency stimulation to Schafer collateral was studied and slope, slope ۱۰-۹۰% and amplitude of field excitatory field potential (fEPSP) were calculated. The escape latency and traveled path in LPS group were significantly higher than those in the control group while, in LPS-N. sativa group these parameters were significantly lower than those in LPS group. The rats in LPS group spent less time and traveled shorter distance in Q۱ than the rats in the control group while, in LPS-N. sativa group the rats spent more time and traveled longer distance than the rats in LPS group. LPS significantly decreased slope, slope ۱۰-۹۰% and amplitude of fEPSP while, in LPS-N. sativa group these parameters increased compared to LPS group. The results indicated that the hydro-alcohol extract of N. sativa protected against synaptic plasticity and spatial learning and memory impairment induced by LPS in rats.

کلیدواژه ها:

Lipopolysaccharide ، ‎ Long term potentiation ، Nigella sativa L ، Spatial memory ، Synaptic plasticity

نویسندگان

Akbar Anaeigoudari

Department of Physiology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran

Fatemeh Norouzi

Department of Physiology, Esfarayan Faculty of Medical Sciences, Esfarayan, Iran

Azam Abareshi

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran

Farimah Beheshti

Department of Basic Sciences and Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran‎

Azita Aaghaei

Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Naser Shafei

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Zahra Gholamnezhad

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mahmoud Hosseini

Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

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