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Suppression of the malignancy of mammary tumor in mice model by inactivated preparation of Mycobacterium obuense

محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 13، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 49

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https://civilica.com/doc/1818701

شناسه ملی سند علمی:

JR_VRFAN-13-3_014

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Breast cancer (BC) is a significant cause of global mortality in women. This study was aimed to evaluate the immune-activation of malignant BC via the administration of attenuated Mycobacterium obuense. For this purpose, an in vivo model was developed with BALB/c mice. Mice were injected with ۲.۰۰ × ۱۰۶ ۴T۱ cells with breast tumor cell line. Forty-two mice were equally divided into control as well as low dose (۰.۲۰ mg ۱۰۰ µL-۱) and high dose (۰.۵۰ mg ۱۰۰ µL-۱) groups of M. obuense to investigate gene expression in the antitumor effects of M. obuense. In one group, paclitaxel was administrated as a choice drug in BC treatment. Antitumor manners were characterized by cytotoxicity against tumor target cells, size of the tumor and the expression of some BC metastatic genes together with pathology. The MTT assay demonstrated that different concentrations of both low and a high doses of bacteria did present no cytotoxicity effect on ۴T۱ cells. According to our findings, M. obuense significantly repressed tumor growth. M. obuense downregulated the expression of collagen type I alpha ۱ (COLIA۱), cFos, alkaline phosphatase (ALP), claudin ۳ (cldn۳), and conversely, activated transcription factor ۴ (ATF۴) and Twist related protein-۱ (Twist۱). All these alternations induced a decrease in the migratory and invasive capabilities of BC. The result of pathology was indicative of tumor regression in the paclitaxel and HK- M. obuense -recipient group. Thus, it seems most likely that M. obuense might impinge upon cell growth and metastatic behavior of malignant cells exerting anti-tumor activity in BC.

کلیدواژه ها:

Breast cancer ، Gene expression ، Immunotherapy ، metastatic behavior ، Mycobacterium obuense

نویسندگان

Katayoon Nofouzi

Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Parsa Almasi

Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Ali Asghar Fakhri-Demeshgheieh

Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Monireh Khordadmehr

Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Behzad Baradaran

Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Milad Asadi

Immunology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Parvin Sarbakhsh

Department of Statics and Epidemiology, Faculty of Health Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

Gholamreza Hamidian

Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

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  • Khordadmehr M, Shahbazi R, Ezzati H, et al. Key microRNAs ...
  • Ho BY, Lin CH, Apaya MK, et al. Silibinin and ...
  • Sarkar FH, Li Y. Using chemopreventive agents to enhance the ...
  • Fowler D, Dalgleish A, Liu W. A heat-killed preparation of ...
  • Bazzi S, Modjtahedi H, Mudan S, et al. Immuno-modulatory effects ...
  • Stebbing J, Dalgleish A, Gifford-Moore A, et al. An intra-patient ...
  • Dalgleish AG, Stebbing J, Adamson DJ, et al. Randomised, open-label, ...
  • Fowler DW, Copier J, Wilson N, et al. Mycobacteria activate ...
  • Wörmann SM, Diakopoulos KN, Lesina M, et al. The immune ...
  • Ghazanchaei A, Mansoori B, Mohammadi A, et al. Restoration of ...
  • Atiya HI, Dvorki-Gheva A, Hassell J, et al. Intraductal adoptation ...
  • Eralp Y, Wang X, Wang JP, et al. Doxorubicin and ...
  • Kidner TB, Morton DL, Lee DJ, et al. Combined intralesional ...
  • Soliman H, Mediavilla-Varela M, Antonia SJ. A GM-CSF and CD۴۰L ...
  • Liu H, Innamarato PP, Kodumudi K, et al. Intralesional rose ...
  • Rajeh MA, Kwan YP, Zakaria Z, et al. Acute toxicity ...
  • Zhang L, Wang Y, Zhang B, et al. Claudin-۳ expression ...
  • Rousseau RF, Haight AE, Hirschmann-Jax C, et al. Local and ...
  • Wang Q, Yu H, Zhang L, et al. Adenovirus-mediated intratumoral ...
  • Ansieau S, Morel AP, Hinkal G, et al. TWISTing an ...
  • Croset M, Goehrig D, Frackowiak A, et al. TWIST۱ expression ...
  • Beck B, Lapouge G, Rorive S, et al. Different levels ...
  • Xu Y, Lee DK, Feng Z, et al. Breast tumor ...
  • Qin Q, Xu Y, He T, et al. Normal and ...
  • Takanami I, Takeuchi K, Kodaira S. Tumor-associated macrophage infiltration in ...
  • Liu C, Li Z, Wang L, et al. Activating transcription ...
  • Unni E, Kittrell FS, Singh U, et al. Osteopontin is ...
  • Wei R, Wong JPC, Kwok HF. Osteopontina promising biomarker for ...
  • Bland KI, Konstadoulakis MM, Vezeridis MP, et al. Oncogene protein ...
  • Lu C, Shen Q, DuPré E, et al. cFos is ...
  • Hop HT, Arayan LT, Huy TX, et al. The key ...
  • Ren HY, Sun LL, Li HY, et al. Prognostic significance ...
  • Pautke C, Schieker M, Tischer T, et al. Characterization of ...
  • Ali NN, Harrison MA, Rowe J, et al. Spectrum of ...
  • Xiao Y, Lu J, Chang W, et al. Dynamic serum ...
  • Kim JM, Kwon CHD, Joh JW, et al. The effect ...
  • Wang Y, Xu H, Zhu B, et al. Systematic identification ...
  • Willis CM, Klüppel M. Chondroitin sulfate-E is a negative regulator ...
  • Feng YX, Sokol ES, Del Vecchio CA, et al. Epithelial-to-mesenchymal ...
  • Guo W, Keckesova Z, Donaher JL, et al. Slug and ...
  • Limia CM, Sauzay C, Urra H, et al. Emerging roles ...
  • Liu S, Liao G, Li G. Regulatory effects of COL۱A۱ ...
  • Lin X, Shang X, Manorek G, et al. Regulation of ...
  • Muhammad N, Bhattacharya S, Steele R, et al. Involvement of ...
  • Rao SR, Snaith AE, Marino D, et al. Tumour-derived alkaline ...
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