Spasmolytic effect of ۱,۸ cineole is mediated through calcium channel blockade in the bovine ileum
محل انتشار: گفتمان پژوهش دامپزشکی، دوره: 13، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 54
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شناسه ملی سند علمی:
JR_VRFAN-13-3_009
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Gastrointestinal motility disorders include increased or decreased movements. Other studies have shown that herbal components, for example, essential oils can modify the increase and decrease of gastrointestinal movements of ruminants. The ۱, ۸-cineole being obtained from the essential oil of many plants has several effects. The present study has investigated the effect of ۱, ۸-cineole on the contractility of bovine ileum smooth muscle. The experiment was performed on the circular smooth muscle of ileum samples taken from slaughtered cows in the organ bath. Seven cumulative concentrations of ۱, ۸-cineole from ۱.۰۰ to ۱,۰۰۰ µg mL-۱ were added to tissue samples. The used solution was Tyrode’s solution aerated with a mixture of ۹۵.۰۰% oxygen and ۵.۰۰% carbon dioxide, and the temperature was set at ۳۷.۰۰ ˚C. The effects of ۱, ۸-cineole on baseline contractions and three induced contractions with barium chloride, potassium chloride, and carbachol were investigated. The effects of ۱, ۸-cineole, and verapamil (standard calcium channel blocker) on calcium channels were assessed. The results revealed that ۱, ۸-cineole significantly inhibited spontaneous contractions as well as all spasmogen-induced contractions. The ۱, ۸-cineole exerts its myorelaxant properties by inhibiting calcium channels in smooth muscle. It seems that ۱, ۸-cineole has a good potential for producing antispasmodics or gastrointestinal motility modulators in veterinary medicine.
کلیدواژه ها:
نویسندگان
Yaser Nozohour
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Masoud Maham
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Bahram Dalir-Naghadeh
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
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