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مقالات فارسیISIکنفرانسهاژورنالها

Evaluation and Diagnosis of Prognostic Factors Affecting the Survival of Leukemia Patients Using Cumulative Incidence Function

محل انتشار: مجله سرطان خاورمیانه، دوره: 14، شماره: 1
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 54

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لینک ثابت به این مقاله:
https://civilica.com/doc/1819086

شناسه ملی سند علمی:

JR_MISJ-14-1_009

تاریخ نمایه سازی: 25 آبان 1402

چکیده مقاله:

Background: Acute lymphoblastic leukemia (ALL) accounts for ۲۵% of cancers among children less than ۱۵ years of age. This study aimed to evaluate and determine the prognostic factors affecting the survival of leukemia patients using cumulative incidence function.Method: This was a retrospective study done on ۱۷۶ children under ۱۵ who had ALL between ۲۰۱۱ and ۲۰۱۹. Overall survival, event-free survival, disease-free survival (DFS), and non-relapse mortality served as the study's endpoints. Using the Fine-Gray model, the Kaplan-Meier, single-variable, and multivariable analyses were conducted. Schwenfeld weighted residuals were used to test the proportional hazard hypothesis. SAS was used to conduct the analysis.Results: The hazard ratio (HR) of DFS for effective variables was calculated (girls compared to boys: ۰.۳۷ [۹۵% confidence interval (CI): ۰.۱۵-۰.۹۱], positive testis test: ۱۰.۳۴ [۹۵% CI: ۴.۴۴-۲۴.۰۵], children with central nervous system involvement: ۲.۹۵ [۹۵% CI: ۱.۳۶-۶.۴۰], testicular swelling in children: ۱۱.۵۴ [۹۵% CI: ۴.۲۱-۳۱.۵۹], children with hepatosplenomegaly larger than ۲ cm: ۰.۳۰ [۹۵% CI: ۰.۱۰-۰.۸۸], high risk of disease compared to low risk: ۴.۷۶ [۹۵% CI: ۱.۱۲-۲۰.۲۲], children with complete remission in ۲۸th day compared with no complete remission: ۰.۱۰ [۹۵% CI: ۰.۰۴- ۰.۲۵]. Only hemoglobin was substantially linked with DFS in the multivariate DFS HR. Children who got radiation had a ۷۷% reduced risk of non-recurrence death than those who did not (HR: ۰.۲۳, ۹۵% CI: ۰.۰۸-۰.۶۰).Conclusion: Being a girl, having family history, and not having radiotherapy were the main factors to develop death before the first recurrence in children.

کلیدواژه ها:

Leukemia ، Neoplasms ، Child ، Survival

نویسندگان

Hamid Reza Khalkhali

Patient Safety Research Center, Department of Biostatistics and Epidemiology, Urmia University of Medical Sciences, Urmia, Iran

Mehran Noroozi

Department of Pediatric Hematology, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran

Robabeh Bahadori

Department of Pediatrics, Urmia University of Medical Sciences, Urmia, Iran

Tahereh Omidi

Department of Biostatistics, Hamadan University of Medical Sciences, Hamadan, Iran

Farid Ghazizadeh

Department of Pediatric Hematology, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran

Sasan Hejazi

Department of Pediatric Hematology, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran

Masoumeh Mahdi-Akhgar

Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran

Rohollah Valizadeh

Urmia University of Medical Sciences, Urmia, Iran

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