Prognosis of Gastric Cancer Patients with a Large Tumor Size
محل انتشار: مجله سرطان خاورمیانه، دوره: 13، شماره: 4
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 48
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شناسه ملی سند علمی:
JR_MISJ-13-4_010
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Background: We evaluated the predictive factors associated with survival for gastric cancer patients with large tumor size (≥۱۰ cm).Method: In this retrospective study, we investigated ۲۷۹ gastric cancer patients with large-sized tumors, treated at the Chonnam National University Hospital, Gwangju, Korea. We analyzed the clinicopathological features and predictive factors associated with survival in these gastric cancer patients with large tumors. Survival was calculated using the Kaplan-Meier method and the relative prognostic importance of the parameters was investigated through Cox's proportional hazards model.Results: The recurrence rates were significantly different between the large and small tumor groups (۷۶.۳% and ۳۶.۶%, respectively; P < ۰.۰۰۱). Multivariate analysis showed that the presence of serosal invasion, nodal involvement, the extent of lymph node dissection, the presence of peritoneal dissemination, and curability had prognostic effects in gastric cancer patients with large-sized tumors. The ۵-year survival rate was lower in patients with tumors ≥۱۰ cm compared with those with smaller tumors (۲۳.۶% versus ۵۷.۰%, respectively; P < ۰.۰۰۰۱). The ۵-year survival rate was higher in patients with large tumor size who underwent curative resection (۳۹.۱%) than those who did not (۱۰.۰%) (P < ۰.۰۰۰۱).Conclusion: The long-term survival of gastric cancer patients with large-sized tumors is related to curative resection. Thus, curative resection is of significance for predicting survival.
کلیدواژه ها:
نویسندگان
Ho Gun Kim
Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
Dong Yeon Gang
Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
Jae Hyuk Lee
Department of Pathology, Chonnam National University Medical School, Gwangju, Korea
Dong Yi Kim
Division of Gastroenterologic Surgery, Department of Surgery, Chonnam National University Medical School, Gwangju, Korea
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