Deranged Lipid Profiles and Hepatocellular Carcinoma: Clinical Significance and Association
محل انتشار: مجله سرطان خاورمیانه، دوره: 13، شماره: 2
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 48
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شناسه ملی سند علمی:
JR_MISJ-13-2_008
تاریخ نمایه سازی: 25 آبان 1402
چکیده مقاله:
Background: The increasing incidence of hepatocellular carcinoma (HCC) is a challenging health problem worldwide with poor prognosis and limited treatment options. The association between metabolic factors and HCC has been documented, however, there is a shortage of data about this association in our locality. Therefore, we aimed to determine the pattern of lipid profile in cirrhotic patients with HCC and investigate the association between dyslipidemia and HCC.Method: In this case-control hospital-based study, serum lipid profile [total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and very-low-density lipoprotein (VLDL)] was determined in ۱۰۰ patients with cirrhosis and ۱۰۰ patients with cirrhosis and HCC. Multivariate analysis of HCC risk factors was done.Results: Metabolic syndrome, hypertriglyceridemia, hypercholesterolemia, high LDL, and combined dyslipidemia were significantly more frequent in HCC patients than non-HCC patients. Low HDL and dyslipidemia were significantly associated with the late HCC stages and LDL levels were significantly correlated with α- fetoprotein levels. There was a tendency towards increasing the values of the other lipid parameters in advanced stages. Metabolic syndrome and combined dyslipidemia were associated with HCC risk.Conclusion: Deranged lipid profiles were common in HCC patients. Metabolic syndrome and combined dyslipidemia could be potential risk factors for HCC and may offer a useful strategy for risk stratification; thus, their control can reduce the HCC burden.
کلیدواژه ها:
نویسندگان
Ehab Moustafa
Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
Elham Hassan
Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
Mohamed Mahmoud
Fever Hospital, Ministry of Health, Sohag, Egypt
Amal Mahmoud
Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt
Mohamed Ghaliony
Department of Gastroenterology and Tropical Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt
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