INTRODUCTION: The most common cancer among womenworldwide is cervical cancer. In antitumor chemotherapy, cisplatin,is used as a first-line chemotherapeutic drug in the treatmentof cervical cancer. Different studies have reported a varietyof toxic events, including arrhythmias, congestive heart failure,electrocardiographic changes, and myocarditis. The most commoncisplatin toxicity side effects are nausea and vomiting. It iscurrently being explored to reduce the side effects of treatmentsby considering less invasive drug delivery methods, such as developingnano-delivery systems that control and target the deliveryof drugs to the desired therapeutic sites. It is possible fornano-size carriers to be magnetically responsive, which allowsthem to be manipulated or triggered by external magnets withoutinvasive procedures for therapeutic or diagnostic purpose.This study aimed to determine the antitumor effects of free cisplatinenhancement in cervical cancer cells by using cisplatin-Encapsulated Fe۳O۴@SiO۲@N-Chit-FA.Materials and Methods: The TC۱ cells were subcutaneouslyinjected into the left flank of each Male C۵۷BL۶ mice. Whenthe tumor size reached to ۷۰-۱۰۰ mm۳, the animals were dividedinto three groups: I. tumor group (received normal saline asvehicle of drug), II. Cisplatin group (treated with cervical cancerstandard treatment, cisplatin), III.Fe۳O۴@SiO۲@nanochi/FA-cis group (treated with Fe۳O۴@SiO۲@NChi/FA-cis). Ingroup III, a circular magnetic field was applied externally. Thetumors size were measured every other day. Cervical tumorsfrom mice were dissected and weighted and a part of tumorstained with hematoxylin and eosin (H&E) for evaluation oftumor necrosis.RESULTS: The results showed that the released drug wouldinduce its effects on a specific target area when an externalmagnetic field was applied, and Fe۳O۴@SiO۲@N-Chit-FAciscan suppress tumor growth more than cisplatin alone viainduction of tumor necrosis. All treated groups showed morenecrosis areas than the control group. Use of cisplatin andFe۳O۴@SiO۲@N-Chit-FA-cis enhanced the necrotic area, butin Fe۳O۴@SiO۲@N-Chit-FA-cis group, the necrotic area wassignificantly more than in mice who treated with cisplatin alone