Intercalation of Mefenamic Acid in Inorganic Nanomatrices with LayeredStructure

In this study, Mefenamic acid was intercalated into Mg-Al layered double hydroxides(LDHs) by ion exchange or coprecipitation methods to obtain mefenamic -LDHs nanohybrids.Mefenamic acid is one of the non-steroidal anti-inflammatory drugs that is used to treat sometypes of acute and chronic diseases. But its low dissolution rate is a limiting factor for itsabsorption, so in order to increase the solubility of this material, it can be used to intercalate itbetween LDH layers. Powder x-ray diffraction (XRD), Fourier transform infrared spectra (FTIR),and elemental analyses indicate a successful intercalation of Mefenamate anions with avertical orientation. Intercalation of Mefenamate anions into Mg-Al LDH caused the interlayerspacing of LDH to increase from ۰.۷۶ to۲.۱ nm as determined by x-ray diffraction studies. TGanalyses propose that the thermal stability of the intercalated organic anion of mefenamate islargely improved compared to the pure form before intercalation.Furthermore, in vitro drugrelease experiments in pH ۷.۴ phosphate buffer solution have been investigated. The drugmolecules during dissolution were exchanged with anions in the medium, this leading to a slowrelease, much slower than when the same matrix was used simply mixed with the drug[۱-۵].