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مقالات فارسیISIکنفرانسهاژورنالها

Low in vitro activity of sertaconazole against clinical isolates of dermatophyte

محل انتشار: سرطان معده، دوره: 6، شماره: 1
سال انتشار: 1399
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 58

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https://civilica.com/doc/1838007

شناسه ملی سند علمی:

JR_CUMM-6-1_006

تاریخ نمایه سازی: 11 آذر 1402

چکیده مقاله:

Background and Purpose: Dermatophytes are a group of fungi specialized in invading humans and other vertebrate keratinized tissues. These fungi cause a variety of skin, nail, and hair disorders, called dermatophytosis (tinea). In some cases, drug resistance to antifungals necessitates special treatment. Among the antifungal agents, sertaconazole (i.e., a third-generation imidazole) has a broad-spectrum against dermatophyte species. Regarding this, the present study was conducted to investigate the antifungal susceptibility of dermatophytes obtained from patients with dermatophytosis in Mashhad located in northeastern Iran. Materials and Methods: A total of ۷۵ clinical dermatophyte isolates, including Trichophyton mentagrophytes (n=۲۱), T. interdigitale (n=۱۸), T. tonsurans (n=۱۶), Epidermophyton floccosum (n=۱۱), Microsporum canis (n=۵), Nannizzia fulvum (n=۲), T. benhamiae (n=۱), and T. verrucosum (n=۱), were evaluated against five antifungal agents of sertaconazole, itraconazole, clotrimazole, terbinafine, and griseofulvin based on the CLSI M۳۸-A۲ guideline. Results: According to the results, the minimum inhibitory concentration (MIC) ranges of sertaconazole, terbinafine, griseofulvin, itraconazole, and clotrimazole were estimated at ۰.۱۲۵-۱۶, ۰.۰۰۲-۱, ۰.۵-۴, ۰.۰۳۱-۴, and ۰.۰۱۶-۴ μg/ml, respectively, for dermatophyte species. In addition, the geometric mean (GM) values of the MIC of sertaconazole, terbinafine, griseofulvin, itraconazole, and clotrimazole were obtained as ۳.۳۹, ۱, ۱.۴۴, ۱.۵۲, and ۱.۹۳, respectively. Conclusion: Among the tested antifungals, terbinafine and griseofulvin were the most effective agents against dermatophyte isolates. However, sertaconazole, a third-generation imidazole, did not show any significant effect. Furthermore, M. canis and E. floccosum showed the best response to the antifungal agents.

کلیدواژه ها:

antifungal drugs ، dermatophytes ، Mashhad ، Microdilution ، Sertaconazole

نویسندگان

Mahsa Behnam

Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Hossein Zarrinfar

Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Javad Najafzadeh

Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ali Naseri

Department of Parasitology and Mycology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Lida Jarahi

Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Monika Novak Babič

Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia

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