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Clinical, epidemiological, and mycological features of patients with candidemia: Experience in two tertiary referral centers in Iran

محل انتشار: مجله قارچ شناسی پزشکی، دوره: 8، شماره: 3
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 70

فایل این مقاله در 9 صفحه با فرمت PDF قابل دریافت می باشد

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لینک ثابت به این مقاله:
https://civilica.com/doc/1838039

شناسه ملی سند علمی:

JR_CUMM-8-3_002

تاریخ نمایه سازی: 11 آذر 1402

چکیده مقاله:

Background and purpose: Candidemia is a major cause of morbidity and mortality among patients receiving immunosuppressive therapy and those hospitalized with serious underlying diseases. Here, we investigated the epidemiological, clinical and mycological features of candiemia in Tehran, Iran.Material and methods: A prospective observational study of all patients diagnosed with candidemia was performed at two referral teaching hospitals in Tehran, Iran between February to December ۲۰۱۸. Demographic characteristics, underlying diseases, risk factors, clinical symptoms, and laboratory analyses of candidemic patients with positive culture were mined. Candida isolates were molecularly identified by sequencing of the internal transcribed spacer region (ITS۱-۵.۸S-ITS۲). The antifungal susceptibility testing for fluconazole, itraconazole, voriconazole, posaconazole, amphotericin B, caspofungin, micafungin and anidulafungin against the isolates were performed using CLSI broth microdilution reference method (M۲۷-A۳).Results: A total of ۸۹ episodes were identified, with an incidence of ۲.۱ episodes/۱۰۰۰ admissions. The most common underlying disease was sepsis (۴۸%) followed by malignancy (۴۶%), renal failure/dialysis (۴۴%), and hypertension (۴۰%). The overall crude mortality was ۴۷%. C. albicans (۴۴%) was the most frequent causative agent followed by C. glabrata (۲۱%), C. parapsilosis complex (۱۵%), C. tropicalis (۱۱%), and C. lusitaniae (۳.۵%). All the isolates were susceptible to amphotericin B. The activity of all the four azoles was low against non-albicans Candida species, especially C. tropicalis.Conclusion: Increase in non-albicans Candida species with reduced susceptibility to antifungal drugs might be alarming in high-risk patients. Therefore, accurate knowledge of predisposing factors and epidemiological patterns in candidemia are effective steps for managing and decreasing the mortality rate in candidemia.

کلیدواژه ها:

Candidemia ، Antifungal susceptibility ، Epidemiology ، risk factors

نویسندگان

Mohammad Kord

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Mohammadreza Salehi

Research center for antibiotic stewardship and antimicrobial resistance, Department of infectious diseases and Tropical Medicine, Imam Khomeini

Seyed Jamal Hashemi

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Alireza Abdollahi

Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Neda Alijani

Department of Infectious Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Ayda Maleki

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Shahram Mahmoudi

Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Kazem Ahmadikia

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Nasrin Parsameher

Clinical Laboratory, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Masoud Moradi

Department of Biostatistics and Epidemiology, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

Mahsa Abdorahimi

Department of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

Sara Rezaie

Department of Chemistry and Biology, Ryerson University, Toronto, Canada

Shirin Sadat Hashemi Fesharaki

Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

Kiana Abbasi

Department of Microbiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran

Laura Alcazar-Fuoli

Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain

Sadegh Khodavaysi

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

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