First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-۱۹ in Iran and review of recent literature

Mojtaba Taghizadeh Armaki; Jalal Jafarzadeh; Saeid Mahdavi Omran; masoumeh Bayani; Ali Tavasoli; Leila Faeli; Mohsen Nosratabadi; Sanaz Yaalimadad; Bahador Nikoueian; Iman Haghani; Maryam Moazeni; Tahereh Shokohi; Mohammad T. Hedayati; Mahdi Abastabar

First report of rhino-orbital mucormycosis caused by Syncephalastrum racemosum in a diabetic patient with COVID-۱۹ in Iran and review of recent literature

محل انتشار: سرطان معده، دوره: 8، شماره: 2

سال انتشار: 1401

نوع سند: مقاله ژورنالی

زبان: انگلیسی

مشاهده: 67

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https://civilica.com/doc/1838042

شناسه ملی سند علمی:

JR_CUMM-8-2_008

تاریخ نمایه سازی: 11 آذر 1402

چکیده مقاله:

Background and Purpose: Invasive mucormycosis is a rare mycosis that affects most cases of uncontrolled diabetes and has a high mortality rate. Patients with COVID-۱۹ are at high risk of developing invasive mucormycosis due to the consumption of anti inflammatory drugs such as corticosteroids and dexamethasone. Rhizopus species followed by Rhizomucor spp. and Mucor spp. are the main common etiological agents of rhino-orbital mucormycosis. Therefore, this study aimed to present a case of mucormycosis due to Syncephalastrum racemosum in a diabetic patient with COVID-۱۹ for the first time in Iran.Case report: A ۷۳-year-old diabetic female was referred to Ayatollah Rouhani Hospital in Babol, Iran, with a confirmed COVID-۱۹ diagnosis, based on positive RT-PCR and computed tomography of the lungs. She has received methylprednisolone due to severe lung complications. Nasal involvement and left orbital swelling were observed ۲۰ days after the hospitalization. By sinus endoscopic surgery, debridement was done and histopathology indicated wide hyphae (without septa). The sequenced PCR products displayed Syncephalastrum racemosum. In the antifungal susceptibility test, amphotericin B showed good activity against S. racemosum and the patient survived with timely treatment.Conclusion: This is the first case report of rhino-orbital mucormycosis due to S. racemosum in COVID-۱۹ patient; therefore, S. racemosum can be considered one of the etiological factors of rhino-orbital mucormycosis in COVID-۱۹ cases.

کلیدواژه ها:

COVID-۱۹ ، Mucormycosis ، Syncephalastrum racemosum

نویسندگان

Mojtaba Taghizadeh Armaki

Department of Medical Mycology and Parasitology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

Jalal Jafarzadeh

Department of Medical Mycology and Parasitology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

Saeid Mahdavi Omran

Department of Medical Mycology and Parasitology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

masoumeh Bayani

Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Ali Tavasoli

Clinical Research Developm ent Unit of Babol University of Ayatollah Rouhani Hospital, Babol University of Medical S ciences, Babol, Iran

Leila Faeli