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مقالات فارسیISIکنفرانسهاژورنالها

Epidemiology, risk factors, species distribution, and antifungal susceptibility of candidemia among hospitalized patients with COVID-۱۹

محل انتشار: مجله قارچ شناسی پزشکی، دوره: 7، شماره: 4
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 50

فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1838063

شناسه ملی سند علمی:

JR_CUMM-7-4_003

تاریخ نمایه سازی: 11 آذر 1402

چکیده مقاله:

Background and Purpose: The pandemic of COVID-۱۹ has caused a worldwide healthcrisis. Candidemia is a potentially lethal condition that has not yet been enough discussed in patients with COVID‐ ۱۹. The current study aimed to investigate the prevalence of candidemia among Iranian COVID‐ ۱۹ patients and characterize itscausative agents and the antifungal susceptibility pattern.Materials and Methods: The present cross-sectional survey was carried out fromMarch ۲۰۲۰ to March ۲۰۲۱ at Imam Khomeini Hospital, Tehran, Iran. Bloodspecimens were obtained from patients with confirmed coronavirus infection who alsohad criteria for candidemia and were examined for any Candida species by conventional and molecular techniques. Susceptibility of isolates to amphotericin B,voriconazole, itraconazole, fluconazole, caspofungin, and ۵-flucytosine was testedusing the CLSI broth dilution technique.Results: In total, ۱۵۳ patients with COVID-۱۹ were included and candidemia wasconfirmed in ۱۲ (۷.۸ %) of them. The majority of patients were ≥ ۵۰ years of age (n=۹)and female (n=۸). Moreover, ۶ out of the ۱۲ patients were diabetic. The presence ofcentral venous catheters, broad-spectrum antibiotic therapy, ICU admission, andmechanical ventilation was observed in all patients. The C. albicans (n=۷, ۵۸.۳ %) andC. dubliniensis (n=۲, ۱۶.۷%) were the most common isolated species. Amphotericin Band ۵-flucytosine were the most active drugs. Despite antifungal treatment, ۴ out of ۱۲patients (۳۳.۳ %) died.Conclusion: Due to the high mortality, the early diagnosis and proper treatment ofcandidemia are essential requirements for optimal clinical outcomes in COVID-۱۹ patients.

کلیدواژه ها:

Candidemia ، C. albicans ، C. dubliniensis ، COVID-۱۹ ، Iran

نویسندگان

Hasti Kamali Sarvestani

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Shahram Mahmoudi

Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran

Pegah Afarinesh khaki

Department of Molecular Genetics, Faculty of Advanced science and Technology, Islamic Azad University, Tehran, Iran

Saham Ansari

Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Sara Ghaderkhani

Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Davoud Roostaei

Department. of Pharmacology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Roshanak Daie Ghazvini

Department of Infectious Diseases, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

Seyed Jamal Hashemi

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Zahra Rafat

Department. of Medical Microbiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Alireza Abdollahi

Department of Pathology, Imam Hospital Complex, Tehran University of Medical Sciences Tehran, Iran

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