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مقالات فارسیISIکنفرانسهاژورنالها

In vitro activity of four triazole antifungal drugs against clinically common and uncommon yeast species

محل انتشار: سرطان معده، دوره: 5، شماره: 4
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 69

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لینک ثابت به این مقاله:
https://civilica.com/doc/1838088

شناسه ملی سند علمی:

JR_CUMM-5-4_003

تاریخ نمایه سازی: 11 آذر 1402

چکیده مقاله:

Background and Purpose: Incidence of fungal infections caused by opportunistic fungal pathogens, such as yeasts and yeast-like species, has undergone an increase in otherwise healthy individuals. These pathogens account for high mortality and show reduced susceptibility to the routine antifungal drugs. Accordingly, antifungal susceptibility testing is an urgent need in the determination of the susceptibility spectrum of antifungals and selection of appropriate antifungal agents for the management of patients with fungal infection. Materials and Methods: The present study was conducted on ۱۱۰ yeast strains belonging to ۱۵ species recovered from clinical specimens. Susceptibility of the isolates to four antifungal drugs (i.e., fluconazole, itraconazole, voriconazole, and posaconazole) was tested according to the Clinical and Laboratory Standards Institute guidelines M۲۷-A۳ and M۲۷-S۴. Results: Fluconazole exhibited no activity against ۴.۳% (n=۲) of C. albicans isolates, whereas the remaining ۴۴ isolates had a minimum inhibitory concentration (MIC) range of ۰.۱۲۵-۴ μg/ml. Voriconazole had the lowest geometric mean MIC (۰.۰۳ μg/ml) against all isolated yeast species, followed by posaconazole (۰.۰۷ μg/ml), itraconazole (۰.۱۰ μg/ml), and fluconazole (۰.۶۰ μg/ml). Overall, all of the isolates had reduced voriconazole MICs with a MIC range of ۰.۰۱۶-۰.۵ μg/ml, except for one isolate of C. albicans that had a MIC of ۱ μg/ml. Candida haemulonii as a multidrug-resistant fungus showed a fluconazole MIC of > ۶۴ μg/ml. Conclusion: The current study provides insight into the antifungal susceptibility profiles of clinically common and uncommon yeast species to four triazole antifungal agents. According to our findings, voriconazole was the most active agent. Awareness about antifungal susceptibility patterns is highly helpful in the selection of appropriate antifungal drugs and identification of the efficiency of the currently used agents.

کلیدواژه ها:

Antifungal agents ، In vitro susceptibility ، Yeast species

نویسندگان

Narges Aslani

Infectious and Tropical Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran

Tahereh Shokohi

Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Mohammad Reza Ataollahi

Department of Medical Immunology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Saham Ansari

Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Yousef Gholampour

Department of Internal Medicine, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

Ali Khani Jeihooni

Department of Public Health, School of Health, Fasa University of Medical Sciences, Fasa, Iran

Mohammad hosein Afsarian

Department of Medical Mycology and Parasitology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran

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