Long-term effect of antifungal therapy for the treatment of severe resistant asthma: an active comparator clinical trial
محل انتشار: سرطان معده، دوره: 5، شماره: 4
سال انتشار: 1398
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 55
فایل این مقاله در 7 صفحه با فرمت PDF قابل دریافت می باشد
- صدور گواهی نمایه سازی
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_CUMM-5-4_001
تاریخ نمایه سازی: 11 آذر 1402
چکیده مقاله:
Background and Purpose: Itraconazole therapy has been reported to control asthma in severe therapy-resistant asthma with fungal sensitization. The aim of this study was to investigate the impact of anti-fungal therapy on the treatment of severe asthma, irrespective of sensitization. Materials and Methods: This active comparator clinical trial was performed on ۱۱۰ therapy-resistant asthmatic patients who were randomly assigned into two groups of case and control. The patients in the case group were administered ۲۰۰ mg itraconazole twice a day and the control group received ۱۰ mg prednisolone after breakfast for ۴ months. The asthma control test (ACT) which was used as a marker for the global evaluation of treatment effectiveness (GETE) was applied as the primary endpoint parameter. Cough, dyspnea, and sleep disturbance were measured on a scale of ۱-۴, with ۱ representing no symptom and ۴ indicating severe exhausting disturbance. Results: Based on the obtained results, ۷۱% of the itraconazole group demonstrated a marked improvement in the GETE score after a four-month treatment. Itraconazole was able to suppress clinical symptoms, including cough, dyspnea, and night symptoms, and their physical exam was indicative of normalization in ۶۰% of the patients. On the other hand, the patients in the parallel group "prednisolone" were only able to control dyspnea. The ACT score represented a notable improvement with itraconazole (mean: ۱۴ before the trial and >۲۰ after the trial) and spirometry parameters underwent a considerable change from obstructive pattern to normal. Furthermore, adverse effects were only detected in ۶% of itraconazole users. Conclusion: The results of this clinical trial indicted the effectiveness of antifungal therapy for the control of the clinical condition of a subgroup of patients with severe steroid-refractory asthma.
کلیدواژه ها:
نویسندگان
Majid Mirsadraee
Internist and pulmonologist, Academic Professor, Islamic Azad University- Mashhad Branch, Mashhad, Iran
Sanaz Dehghan
Innovative Research Center, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran
Shadi Ghaffari
MSc in Biology, Research Department, Kavosh High School, Mashhad, Iran
Niloofar Mirsadraee
MSc in Cell and Molecular Biology, Innovative Research Center, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran
مراجع و منابع این مقاله:
لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :