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مقالات فارسیISIکنفرانسهاژورنالها

Evaluation of Bone Mineral Density in Juvenile Systemic Lupus Erythematosus

محل انتشار: مجله استخوان و جراحی عمومی، دوره: 11، شماره: 12
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 52

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لینک ثابت به این مقاله:
https://civilica.com/doc/1845123

شناسه ملی سند علمی:

JR_TABO-11-12_007

تاریخ نمایه سازی: 15 آذر 1402

چکیده مقاله:

Objectives: The present study aimed to determine the prevalence of low bone mineral density (BMD)and low bone mineral content (BMC) as chronic complications of juvenile systemic lupus erythematosus(JSLE) and identify the associated variables and patient characteristics to investigate the relationshipbetween BMD and influential factors.Methods: This cross-sectional study enrolled ۵۴ patients with JSLE, including ۳۸ females and ۱۶ males. The BMDand BMC were assessed by dual-energy X-ray absorptiometry in the hip (femoral neck) and the lumbar spine. LowBMD was considered a Z-score < -۲. The study investigated the association of BMC and Z-score with the currentdaily dose of corticosteroids, the daily dose of corticosteroids at disease onset, the duration of disease, the durationof steroid treatment, the time from the onset of symptoms to diagnosis, and renal involvement.Results: The prevalence of low BMD in the lumbar spine and the femoral neck was ۱۴.۸% and ۱۸.۵%, respectively;the reduction of BMD was more significant in the femoral neck compared to the lumbar spine. Osteoporosis wasdetected in one patient. The multiple linear regression analysis found a significant association between a higherdaily corticosteroid dose and lower BMC of the femoral neck and the lumbar spine. In addition, patients receivinghigher doses of corticosteroids at disease onset showed better follow-up bone mineral densitometry results.Conclusion: Based on the findings of this study, JSLE more affects the femoral neck than the lumbar spine. Patientsreceiving a more robust treatment with higher doses of corticosteroids at disease onset (to control the inflammatoryprocesses) showed better spinal BMC results. A higher dose of daily corticosteroid treatment during assessmentwas identified as a risk factor for low BMD. Level of evidence: IV

کلیدواژه ها:

Bone Mineral Content ، Bone mineral density ، Children ، Juvenile Systemic Lupus Erythematous ، SLE

نویسندگان

Mahsa Soti Khiabani

۱ Children’s Medical Center, Pediatrics Center of Excellence, Tehran, Iran ۲ Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran

Fatemeh Tahghighi Sharabian

۱ Children’s Medical Center, Pediatrics Center of Excellence, Tehran, Iran ۲ Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran ۳ Pediatric Rheumatology Society of Iran, Tehran, Iran

Seyyed Reza Raeeskarami,

۲ Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran ۳ Pediatric Rheumatology Society of Iran, Tehran, Iran

Vahid Ziaee

۱ Children’s Medical Center, Pediatrics Center of Excellence, Tehran, Iran ۲ Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran ۳ Pediatric Rheumatology Society of Iran, Tehran, Iran ۴ Pediatric Rheumatology

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